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Abnova
GAK Monoclonal Antibody (4C10)
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Product Details
H00002580-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
4C10
Immunogen
GAK (AAH08668, 151 a.a. approximately 250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: SAVAPTPATE GPLFSPGGQP APCGSQASWT KSQNPDPFAD LGDLSSGLQG SPAGFPPGGF IPKTATTPKG SSSWQTSRPP AQGASWPPQA KPPPKACTQP
Target Information
GAK serine/threonine kinase or Cyclin-G-associated kinase was originally identified as a protein that is associated with cyclin G. However, neither CDK5 nor GAK kinase activity is activated by cyclin G nor does GAK affect CDK5 kinase activity. GAK seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: auxilin-2; Cyclin-G-associated kinase; DnaJ homolog subfamily C member 26; unnamed protein product
Gene Aliases: DNAJ26; DNAJC26; GAK
UniProt ID: (Human) O14976
Entrez Gene ID: (Human) 2580
protein folding
receptor-mediated endocytosis
endoplasmic reticulum organization
Golgi organization
negative regulation of neuron projection development
synaptic vesicle uncoating
protein localization to Golgi apparatus
intracellular transport
clathrin coat assembly
clathrin coat disassembly
clathrin-mediated endocytosis
protein localization to plasma membrane
Golgi to lysosome transport
regulation of clathrin coat assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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