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Abnova
PLD2 Monoclonal Antibody (1C5)
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Product Details
H00005338-M01
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1C5
Immunogen
PLD2 (AAH15033, 834 a.a. approximately 933 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: LRDPICDDFF QLWQDMAESN ANIYEQIFRC LPSNATRSLR TLREYVAVEP LATVSPPLAR SELTQVQGHL VHFPLKFLED ESLLPPLGSK EGMIPLEVWT
Target Information
PLD2 is a peripheral membrane protein belonging to phospholipase D family with a PH domain, two PLD phosphodiesterase domains and a PX (phox homology) domain that plays a regulatory rather than catalytic role. PLD2 catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid and choline. PLD2 may function in regulated secretion, signal-induced cytoskeletal regulation and/or endocytosis, transcriptional regulation, and cell cycle control. It is usually stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and activated by the ADP-ribosylation factor-1 (ARF-1). PLD2 is activated by agonist stimulation of both tyrosine kinase and G protein-coupled receptors and is also known to interact with EGFR and PIP5K1A. PLD2, localized to plasma membrane caveolae, is ubiquitously expressed in most tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Choline phosphatase 2; Phosphatidylcholine-hydrolyzing phospholipase D2; phospholipase D gene 2; Phospholipase D2; PLD 2; PLD1C; rPLD2; splice variant hPLD2a; splice variant hPLD2b; unnamed protein product
Gene Aliases: PLD1C; PLD2; Pldc
UniProt ID: (Human) O14939, (Rat) P70498
Entrez Gene ID: (Human) 5338, (Rat) 25097
G-protein coupled receptor internalization
lipid metabolic process
phosphatidic acid biosynthetic process
receptor-mediated endocytosis
cytoskeleton organization
small GTPase mediated signal transduction
phospholipid catabolic process
lipid catabolic process
intracellular signal transduction
synaptic vesicle recycling
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of vesicle-mediated transport
response to hypoxia
positive regulation of phosphatidylinositol 3-kinase signaling
response to organic cyclic compound
positive regulation of cell migration
neuron projection development
response to hydrogen peroxide
positive regulation of mast cell degranulation
response to peptide hormone
positive regulation of cell adhesion
positive regulation of receptor-mediated endocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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