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Abnova
TANK Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 2
TANK Antibody (H00010010-D01P) in WB
Western Blot analysis of TANK expression in transfected 293T cell line (H00010010-T02) by TANK MaxPab polyclonal antibody.
Lane 1: TANK transfected lysate(13.60 KDa).
Lane 2: Non-transfected lysate.
Lane 1: TANK transfected lysate(13.60 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00010010-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TANK (NP_597841.1, 1 a.a. approximately 119 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV DIASAESSI
Target Information
TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappa-B. This activation of NF-kappa-B occurs through an association with the kinases IKK-iota and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the Ikappa-B complex. This suggests that in addition to the possibility that TBK1 and IKK-iota activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kappa-B proteins. At least two isoforms of TANK are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: I-TRAF; OTTHUMP00000200694; OTTHUMP00000200695; OTTHUMP00000200696; OTTHUMP00000200698; OTTHUMP00000200700; OTTHUMP00000200703; OTTHUMP00000200704; TRAF family member-associated NF-kappa-B activator; TRAF-interacting protein; unnamed protein product
Gene Aliases: I-TRAF; ITRAF; TANK; TRAF2
UniProt ID: (Human) Q92844
Entrez Gene ID: (Human) 10010
cellular response to DNA damage stimulus
signal transduction
negative regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of type I interferon production
negative regulation of I-kappaB kinase/NF-kappaB signaling
defense response to virus
type I interferon signaling pathway
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to ionizing radiation
positive regulation of protein deubiquitination
positive regulation of ubiquitin-specific protease activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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