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Abnova
BLNK Monoclonal Antibody (1D7)
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Product Details
H00029760-M04
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1D7
Immunogen
BLNK (AAH18906, 301 a.a. approximately 400 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: KQIHQKPIPL PRFTEGGNPT VDGPLPSFSS NSTISEQEAG VLCKPWYAGA CDRKSAEEAL HRSNKDGSFL IRKSSGHDSK QPYTLVVFFN KRVYNIPVRF
Target Information
B cell linker protein (Blnk) is a protein encoded by the Blnk gene located on chromosome 10 in humans. It is also known as SLP 65 (Src homology 2 domain-containing leukocyte protein of 65 kDa). It derives its name from being an adaptor protein in the B cell receptor signaling cascade with several supporting studies showing improper development of B cells in the absence of Blnk. Blnk undergoes tyrosine phosphorylation by Syk, a B cell receptor activated kinase, which provides a platform for interaction of signaling intermediaries such as the Vav GEF and Grb2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B cell adaptor containing SH2 domain; B-cell activation; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker protein; Cytoplasmic adapter protein; MGC111051; SLP-65; Src homology 2 domain-containing leukocyte protein of 65 kDa; Src homology [SH2] domain-containing leukocyte protein of 65 kD; unnamed protein product
Gene Aliases: AGM4; BASH; bca; BLNK; BLNK-S; LY57; SLP-65; SLP65
UniProt ID: (Human) Q8WV28, (Rat) Q4KM52
Entrez Gene ID: (Human) 29760, (Rat) 499356
transmembrane receptor protein tyrosine kinase adaptor activity
protein binding
lipid binding
enzyme binding
protein kinase binding
signaling adaptor activity
SH2 domain binding
phospholipase binding
molecular condensate scaffold activity
protein tyrosine kinase binding
molecular_function
SH3/SH2 adaptor activity
scaffold/adaptor protein
inflammatory response
humoral immune response
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of gene expression
B cell differentiation
intracellular signal transduction
B cell activation
B cell receptor signaling pathway
biological_process
positive regulation of signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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