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Abnova
SOX8 Monoclonal Antibody (5A7)
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Product Details
H00030812-M03
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
5A7
Immunogen
SOX8 (NP_055402, 102 a.a. approximately 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: VKRPMNAFMV WAQAARRKLA DQYPHLHNAE LSKTLGKLWR LLSESEKRPF VEEAERLRVQ HKKDHPDYKY QPRRRKSAKA GHSDSDSGAE LGPHPGGGAV YKAEAGLGD
Target Information
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SRY (sex determining region Y)-box 8; SRY-box 8; Transcription factor SOX-8
Gene Aliases: SOX8
UniProt ID: (Human) P57073
Entrez Gene ID: (Human) 30812
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
DNA-binding transcription factor binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
in utero embryonic development
neural crest cell migration
morphogenesis of an epithelium
signal transduction
spermatogenesis
peripheral nervous system development
male gonad development
positive regulation of gene expression
regulation of hormone levels
positive regulation of gliogenesis
neural crest cell development
positive regulation of osteoblast proliferation
skeletal muscle cell differentiation
negative regulation of apoptotic process
cell fate commitment
fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of photoreceptor cell differentiation
cell maturation
enteric nervous system development
oligodendrocyte differentiation
Sertoli cell development
astrocyte fate commitment
retina development in camera-type eye
retinal rod cell differentiation
adipose tissue development
morphogenesis of a branching epithelium
renal vesicle induction
ureter morphogenesis
metanephric nephron tubule formation
positive regulation of kidney development
positive regulation of branching involved in ureteric bud morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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