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Invitrogen
beta Amyloid Monoclonal Antibody (16E9)
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Product Details
HYB 310-04-02
Product Specifications
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
16E9
Immunogen
Synthetic peptide corresponding to residues R(5) H D S G Y E V H H Q K(16) of amyloid b-peptied coupled to S3 + epinephrine.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.96 mg/mL
Amount
192 µg
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
RRID
Product Specific Information
The binding of HYB 310-04-02 to amyloid b-peptide depends on the presence of at least amino acid residues 10-16.
HYB 310-04-02 has been successfully used in ELISA techniques. HYB 310-04-02 was tested by ELISA in wells coated with BSA-coupled synthetic peptides from the amyloid b-peptide.
The HYB 310-04-02 immunogen is a synthetic peptide corresponding to residues R(5) H D S G Y E V H H Q K(16) of amyloid b-peptied coupled to S3 + epinephrine.
Epitope specificity differs from that of HYB 310-03-02 and HYB 310-07-02.
NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP, and a membrane-bound remnant. The remnant protein is processed by another protease, gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a multi-subunit complex containing presenilin-1 and 2 as central components. The transmembrane glycoprotein, nicastrin, is associated with presinilins and has been found to bind to the carboxyl-terminus of beta APP and helps to modulate the production of the amyloid beta peptide. Abeta is an extracellular filamentous protein component of amyloid cores, neuritic plaques and is also found as a deposit in neurofibrillary tangles. Alzheimer's disease, the most common cause of senile dementia, is characterized by abnormal filamentous protein deposits in the brain. Beta amyloid deposits are also detected in Lewy body dementia, Down's syndrome, amyloidosis (Dutch type), cerebroarterial amyloidosis (cerebral amyloid angiopathy) and in the Guam Parkinson-Dementia complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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