Insulin-like growth factor 2 and potential regulators of hemangioma growth and involution identified by large-scale expression analysis.
AuthorsRitter MR, Dorrell MI, Edmonds J, Friedlander SF, Friedlander M
JournalProc Natl Acad Sci U S A
PubMed ID12032304
'Hemangiomas are benign tumors of the vascular endothelium and are the most common tumors of infancy. These tumors are characterized by an initial phase of rapid proliferation, which is followed, in most cases, by spontaneous involution. Although most lesions resolve without complication, there are some cases in which hemangiomas can ... More
Cell fusion-independent differentiation of neural stem cells to the endothelial lineage.
AuthorsWurmser AE, Nakashima K, Summers RG, Toni N, D'Amour KA, Lie DC, Gage FH
JournalNature
PubMed ID15254537
'Somatic stem cells have been claimed to possess an unexpectedly broad differentiation potential (referred to here as plasticity) that could be induced by exposing stem cells to the extracellular developmental signals of other lineages in mixed-cell cultures. Recently, this and other experimental evidence supporting the existence of stem-cell plasticity have ... More
Effects of familial hemiplegic migraine type 1 mutation T666M on voltage-gated calcium channel activities in trigeminal ganglion neurons.
AuthorsTao J, Liu P, Xiao Z, Zhao H, Gerber BR, Cao YQ,
JournalJ Neurophysiol
PubMed ID22190617
'Familial hemiplegic migraine type 1 (FHM-1), a rare hereditary form of migraine with aura and hemiparesis, serves as a good model for exploring migraine pathophysiology. The FHM-1 gene encodes the pore-forming Ca(V)2.1 subunit of human P/Q-type voltage-gated Ca(2+) channels (VGCCs). Some FHM-1 mutations result in a decrease of whole cell ... More
CXCL16 orchestrates adenosine A3 receptor and MCP-1/CCL2 activity to protect neurons from excitotoxic cell death in the CNS.
AuthorsRosito M, Deflorio C, Limatola C, Trettel F,
JournalJ Neurosci
PubMed ID22378888
A role for chemokines as molecules mediating neuron-glia cross talk has emerged in recent years, both in physiological and pathological conditions. We demonstrate here for the first time that the chemokine CXCL16 and its unique receptor CXCR6 are functionally expressed in the CNS, and induce neuroprotection against excitotoxic damage due ... More
Microglial cells in astroglial cultures: a cautionary note.
AuthorsSaura J,
JournalJ Neuroinflammation
PubMed ID17937799
Primary rodent astroglial-enriched cultures are the most popular model to study astroglial biology in vitro. From the original methods described in the 1970's a great number of minor modifications have been incorporated into these protocols by different laboratories. These protocols result in cultures in which the astrocyte is the predominant ... More
Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
Protease-activated receptors (PAR1-4) are activated by proteases released by cell damage or blood clotting, and are known to be involved in promoting pain and hyperalgesia. Previous studies have shown that PAR2 receptors enhance activation of TRPV1 but the role of other PARs is less clear. In this paper we investigate ... More
Activation of protease-activated receptor-1 triggers astrogliosis after brain injury.
AuthorsNicole O, Goldshmidt A, Hamill CE, Sorensen SD, Sastre A, Lyuboslavsky P, Hepler JR, McKeon RJ, Traynelis SF
JournalJ Neurosci
PubMed ID15858058
We have studied the involvement of the thrombin receptor [protease-activated receptor-1 (PAR-1)] in astrogliosis, because extravasation of PAR-1 activators, such as thrombin, into brain parenchyma can occur after blood-brain barrier breakdown in a number of CNS disorders. PAR1-/- animals show a reduced astrocytic response to cortical stab wound, suggesting that ... More
Deafness and stria vascularis defects in S1P2 receptor-null mice.
AuthorsKono M, Belyantseva IA, Skoura A, Frolenkov GI, Starost MF, Dreier JL, Lidington D, Bolz SS, Friedman TB, Hla T, Proia RL
JournalJ Biol Chem
PubMed ID17284444
The S1P(2) receptor is a member of a family of G protein-coupled receptors that bind the extracellular sphingolipid metabolite sphingosine 1-phosphate with high affinity. The receptor is widely expressed and linked to multiple G protein signaling pathways, but its physiological function has remained elusive. Here we have demonstrated that S1P(2) ... More
A-type voltage-gated K+ currents influence firing properties of isolectin B4-positive but not isolectin B4-negative primary sensory neurons.
AuthorsVydyanathan A, Wu ZZ, Chen SR, Pan HL
JournalJ Neurophysiol
PubMed ID15647393
Voltage-gated K+ channels (Kv) in primary sensory neurons are important for regulation of neuronal excitability. The dorsal root ganglion (DRG) neurons are heterogeneous, and the types of native Kv currents in different groups of nociceptive DRG neurons are not fully known. In this study, we determined the difference in the ... More
Satellite glial cells promote regenerative growth in sensory neurons.
Authors
JournalNat Commun
PubMed ID32994417
SUMOylation of VEGFR2 regulates its intracellular trafficking and pathological angiogenesis.
Authors
JournalNat Commun
PubMed ID30120232
Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1.
Authors
JournalCell Metab
PubMed ID23473031
In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni.
Authors
JournalNat Commun
PubMed ID28220790
Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation.
Authors
JournalNat Med
PubMed ID27548575
CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration.
Authors
JournalNat Commun
PubMed ID29748595
A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis.
Authors
JournalNat Commun
PubMed ID29535383
TACAN Is an Ion Channel Involved in Sensing Mechanical Pain.
Authors
JournalCell
PubMed ID32084332
Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1.