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Bethyl Laboratories
GRB10 Polyclonal Antibody
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Product Details
IHC-00614-T
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 100 and 150 of human growth factor receptor-bound protein 10.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
2.5 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon and Crab-eating macaque
Target Information
GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP, and a proline-rich N terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. GRB10 maps to mouse chromosome 11, in close proximity to the EGF receptor. Similarly, GRB7 maps to the same mouse chromosome near the EGF receptor-related protein HER2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Grb-IRgamma/hGrb10gamma; GRB10 adapter protein; GRB10 adaptor protein; Growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; KIAA0207; maternally expressed gene 1; OTTHUMP00000197988; OTTHUMP00000197989; OTTHUMP00000197990; OTTHUMP00000197991; OTTHUMP00000197993; OTTHUMP00000197994; SH2 domain; SH2 domain containing protein; splice variant of Grb10; unnamed protein product
Gene Aliases: Grb-10; GRB-IR; GRB10; GRBIR; IRBP; KIAA0207; MEG1; RSS
UniProt ID: (Human) Q13322
Entrez Gene ID: (Human) 2887
signal transduction
insulin receptor signaling pathway
gene expression
negative regulation of Wnt signaling pathway
positive regulation of vascular endothelial growth factor receptor signaling pathway
response to insulin
positive regulation of phosphorylation
negative regulation of glycogen biosynthetic process
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
insulin-like growth factor receptor signaling pathway
ERK1 and ERK2 cascade
positive regulation of cold-induced thermogenesis
vascular associated smooth muscle cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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