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Bethyl Laboratories
EAF2 Polyclonal Antibody
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Product Details
IHC-00702
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 150 and 200 of human ELL associated factor 2.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Gorilla, Chimpanzee, Crab-eating macaque and White-tufted-ear marmoset
Target Information
EAF1 and EAF2 can form a complex with ELL that targets the ternary elongation complex of Pol II, stimulating the rate of elongation. In addition, EAF1 and EAF2 are important for the stability of the NuA4 histone acetyltransferase complex, which transcriptionally activates certain genes by acetylation of Histones H4 and H2A. Both EAF1 and EAF2 are ubiquitously expressed members of the EAF family that colocalize with ELL to the the Cajal bodies and nuclear speckles. EAF1 contains a C-terminal region rich in aspartic acid, glutamic acid and serine residues. EAF2 is an androgen-response gene and can act as a potent apoptosis inducer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ELL-associated factor 2; Testosterone-regulated apoptosis inducer and tumor suppressor protein; TRAITS; unnamed protein product
Gene Aliases: BM-040; BM040; EAF2; TRAITS; U19
UniProt ID: (Human) Q96CJ1
Entrez Gene ID: (Human) 55840
transcription elongation from RNA polymerase II promoter
apoptotic process
negative regulation of cell growth
regulation of transcription elongation from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
epithelial cell proliferation involved in prostate gland development
negative regulation of epithelial cell proliferation involved in prostate gland development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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