West African Sorghum bicolor leaf sheaths have anti-inflammatory and immune-modulating properties in vitro.
AuthorsBenson KF, Beaman JL, Ou B, Okubena A, Okubena O, Jensen GS,
JournalJ Med Food
PubMed ID23289787
'The impact of chronic inflammatory conditions on immune function is substantial, and the simultaneous application of anti-inflammatory and immune modulating modalities has potential for reducing inflammation-induced immune suppression. Sorghum-based foods, teas, beers, and extracts are used in traditional medicine, placing an importance on obtaining an increased understanding of the biological ... More
Reconstituted high-density lipoprotein modulates activation of human leukocytes.
AuthorsSpirig R, Schaub A, Kropf A, Miescher S, Spycher MO, Rieben R,
Journal
PubMed ID23967171
'An anti-inflammatory effect of reconstituted High Density Lipoprotein (rHDL) has been demonstrated in atherosclerosis and in sepsis models. An increase of adhesion molecules as well as tissue factor expression on endothelial cells in response to inflammatory or danger signals are attenuated by the treatment with rHDL. Here we show the ... More
A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection.
AuthorsSiddle KJ, Deschamps M, Tailleux L, Nédélec Y, Pothlichet J, Lugo-Villarino G, Libri V, Gicquel B, Neyrolles O, Laval G, Patin E, Barreiro LB, Quintana-Murci L,
Journal
PubMed ID24482540
MicroRNAs (miRNAs) are critical regulators of gene expression, and their role in a wide variety of biological processes, including host antimicrobial defense, is increasingly well described. Consistent with their diverse functional effects, miRNA expression is highly context dependent and shows marked changes upon cellular activation. However, the genetic control of ... More
Characterization of monocyte-derived dendritic cells from immunosuppressed renal transplant recipients with and without squamous cell carcinomas.
Renal transplant recipients (RTR) have a high risk of tumour development, especially cutaneous squamous cell carcinomas (SCC), due to long-term immunosuppressive therapy. RTR may develop multiple lesions over short time periods, and these are often more aggressive with a higher risk of local recurrence and metastasis resulting in increased morbidity ... More
In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren's syndrome.
AuthorsVolchenkov R, Brun JG, Jonsson R, Appel S,
Journal
PubMed ID24025795
Therapeutic vaccination with antigen-specific tolerogenic dendritic cells (tolDC) might become a future option of individualized therapy for patients with autoimmune diseases. In this study, we tested the possibility of generating monocyte-derived tolDC from patients with primary Sjögren's syndrome (pSS). We analyzed phenotype, cytokine production and ability to suppress Ro/La-specific immune ... More
Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits.
AuthorsRoybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA
JournalCell
PubMed ID26830879
'T cells can be re-directed to kill cancer cells using chimeric antigen receptors (CARs) or T cell receptors (TCRs). This approach, however, is constrained by the rarity of tumor-specific single antigens. Targeting antigens also found on bystander tissues can cause life-threatening adverse effects. A powerful way to enhance ON-target activity ... More
Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors.
AuthorsRoybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA
JournalCell
PubMed ID27693353
'Redirecting T cells to attack cancer using engineered chimeric receptors provides powerful new therapeutic capabilities. However, the effectiveness of therapeutic T cells is constrained by the endogenous T cell response: certain facets of natural response programs can be toxic, whereas other responses, such as the ability to overcome tumor immunosuppression, are absent. Thus, ... More
Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver.
AuthorsDusséaux M, Masse-Ranson G, Darche S, Ahodantin J, Li Y, Fiquet O, Beaumont E, Moreau P, Rivière L, Neuveut C, Soussan P, Roingeard P, Kremsdorf D, Di Santo JP, Strick-Marchand H
JournalGastroenterology
PubMed ID28851562
Hepatitis B virus (HBV) infects hepatocytes, but the mechanisms of the immune response against the virus and how it affects disease progression are unclear.
Regulatory T cells control toxicity in a humanized model of IL-2 therapy.
AuthorsLi Y, Strick-Marchand H, Lim AI, Ren J, Masse-Ranson G, Dan Li Jouvion G, Rogge L, Lucas S, Bin Li Di Santo JP
JournalNat Commun
PubMed ID29176694
While patient selection and clinical management have reduced high-dose IL-2 (HDIL2) immunotherapy toxicities, the immune mechanisms that underlie HDIL2-induced morbidity remain unclear. Here we show that dose-dependent morbidity and mortality of IL-2 immunotherapy can be modeled in human immune system (HIS) mice. Depletion of human T cell subsets during the ... More
Circulating mitochondria in deceased organ donors are associated with immune activation and early allograft dysfunction.
AuthorsPollara J, Edwards RW, Lin L, Bendersky VA, Brennan TV
JournalJCI Insight
PubMed ID30089724
Brain death that occurs in the setting of deceased organ donation for transplantation is associated with systemic inflammation of unknown origin. It has recently been recognized that mitochondria-derived damage-associated molecular patterns (mtDAMPs) released into the circulation in the setting of trauma and tissue injury are associated with a systemic inflammatory ... More
Single Cell Based Phosphorylation Profiling Identifies Alterations in Toll-Like Receptor 7 and 9 Signaling in Patients With Primary Sjögren's Syndrome.
AuthorsDavies R, Sarkar I, Hammenfors D, Bergum B, Vogelsang P, Solberg SM, Gavasso S, Brun JG, Jonsson R, Appel S
JournalFront Immunol
PubMed ID30846988
Primary Sjögren's syndrome (pSS) is associated with polymorphisms and mRNA expression profiles that are indicative of an exaggerated innate and type I IFN immune response. Excessive activation potential of signaling pathways may play a role in this profile, but the intracellular signaling profile of the disease is not well characterized. ... More