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Invitrogen
Cytokeratin Pan Type I Monoclonal Antibody (AE1)
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Product Details
MA1-26280
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
AE1
Immunogen
Human epidermal keratin.
Conjugate
Form
Liquid
Concentration
2 µg/mL
Amount
12 µg
Purification
IgG fraction
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Skin.
Target Information
Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 40-kDa keratin intermediate filament; Acidic Cytokeratin; Cell proliferation-inducing gene 46 protein; CK-10; CK-14; CK-15; CK-16; CK-18; CK-19; CK-9; cytokeratin 10; cytokeratin 14; cytokeratin 15; cytokeratin 16; cytokeratin 18; cytokeratin 19; cytokeratin 9; Cytokeratin-10; Cytokeratin-14; Cytokeratin-15; Cytokeratin-16; Cytokeratin-18; Cytokeratin-19; Cytokeratin-9; focal non-epidermolytic palmoplantar keratoderma; HMWCK; intermediate filament protein K16; K10; K14; K15; K16; K18; K19; K9; keratin 10, type I; keratin 14, type I; keratin 15, type I; keratin 16 homolog; keratin 16, type I; keratin 18, type I; keratin 19, type I; keratin 9, type I; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 14; Keratin, type I cytoskeletal 15; Keratin, type I cytoskeletal 16; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 9; keratin, type I, 40-kd; Keratin-10; Keratin-14; Keratin-15; keratin-15, basic; keratin-15, beta; Keratin-16; Keratin-18; Keratin-19; Keratin-9; ORF; pan keratin; pankeratin; PIG46; type I cytokeratin; type I cytoskeletal 15; type I cytoskeletal 9; unnamed protein product
Gene Aliases: BCIE; BIE; CK-18; CK-9; CK10; CK14; CK15; CK16; CK19; CYK18; EBS1; EBS1A; EBS1B; EBS1C; EBS1D; EBS3; EBS4; EHK; EHK2; EHK2A; EHK2B; EPPK; EPPK1; FNEPPK; IHL; K10; K14; K15; K16; K18; K19; K1CO; K1CP; K1CS; K9; KPP; KRT10; KRT14; KRT15; KRT16; KRT16A; KRT18; KRT19; KRT9; KRTB; NEPPK; NFJ; PC1; PIG46
UniProt ID: (Human) P13645, (Human) P02533, (Human) P19012, (Human) P08779, (Human) P05783, (Human) P08727, (Human) P35527
Entrez Gene ID: (Human) 3858, (Human) 3861, (Human) 3866, (Human) 3868, (Human) 3875, (Human) 3880, (Human) 3857
structural molecule activity
protein binding
structural constituent of epidermis
protein heterodimerization activity
structural constituent of cytoskeleton
keratin filament binding
scaffold protein binding
RNA binding
cadherin binding involved in cell-cell adhesion
structural constituent of muscle
macromolecular complex binding
morphogenesis of an epithelium
epidermis development
response to radiation
keratinocyte differentiation
hair cycle
intermediate filament organization
intermediate filament bundle assembly
stem cell differentiation
inflammatory response
cytoskeleton organization
negative regulation of cell migration
keratinization
innate immune response
intermediate filament cytoskeleton organization
keratinocyte migration
establishment of skin barrier
Notch signaling pathway
epithelial cell differentiation
response to estrogen
sarcomere organization
cell differentiation involved in embryonic placenta development
spermatogenesis
skin development
peptide cross-linking
positive regulation of epidermis development
protein heterotetramerization
anatomical structure morphogenesis
tumor necrosis factor-mediated signaling pathway
Golgi to plasma membrane protein transport
negative regulation of apoptotic process
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
cell-cell adhesion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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