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Invitrogen
Factor VIII Monoclonal Antibody (F8-2.2.32)
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Product Details
MA1-10588
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
F8-2.2.32
Immunogen
Purified human Factor VIII.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.6 mg/mL
Amount
300 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA1-10588 detects full-length human Factor VIII. This antibody does not cross-react with von Willebrand factor.
MA1-10588 has been successfully used in ELISA and Western blot applications.
The MA1-10588 immunogen is purified human Factor VIII.
Target Information
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antihemophilic factor; coagulation factor VIII A1 domain; coagulation factor VIII C2 domain; coagulation factor VIII, procoagulant component; coagulation factor VIIIc; Factor 8; factor VIII; factor VIII F8B; factor8; preprocoagulation factor VIII:C; RP11-115M6.7; unnamed protein product
Gene Aliases: AHF; DXS1253E; F8B; F8C; FVIII; HEMA; THPH13
UniProt ID: (Human) P00451
Entrez Gene ID: (Human) 2157
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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