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Invitrogen

CD4/CD28 Antibody Cocktail, FITC, PE

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Product Details

MA1-12122

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Cocktail

Type

Antibody

Clone

7E14, B-23

Immunogen

human peripheral blood T lymphocytes and HPB-ALL T-cell line

Conjugate

FITC , PE FITC , PE FITC , PE

Form

Liquid

Purification

Protein A/G

Storage buffer

PBS with 0.2% carrier protein

Contains

0.08% sodium azide

Storage conditions

4°C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1072293

Product Specific Information

This antibody is a monoclonal mixture of FITC-conjugated CD4 (clone 7E14, isotype IgG1) and PE-conjugated CD28 (clone B-23, isotype IgG1).

Target Information

The CD4 antigen is involved in the recognition of the type II MHC antigen. It is also a receptor for HIV. It is present on most T helper cells and normal thymocytes. The cytoplasmic portion of CD4 is associated with p56lck tyrosine kinase. CD4 expression is commonly found in human lymph nodes and tonsils. Human CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells and 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells results in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD4 antigen (p55); CD4 antigen p55; CD4 receptor; MGC138290; T-cell surface antigen T4/Leu-3; T-cell-specific homodimer surface protein precursor; T4 surface glycoprotein precursor; unnamed protein product

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Gene Aliases: CD4mut; IMD123; IMD79; Leu-3; OKT4D; T4; Tp44

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UniProt ID: (Human) P10747, (Human) P01730

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Entrez Gene ID: (Human) 940, (Human) 920

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Function(s)
transmembrane signaling receptor activity protein binding coreceptor activity protein kinase binding identical protein binding virus receptor activity receptor binding extracellular matrix structural constituent zinc ion binding lipid binding immunoglobulin binding enzyme binding MHC class II protein complex binding signaling receptor activity interleukin-16 binding interleukin-16 receptor activity MHC class II protein binding protein homodimerization activity protein tyrosine kinase binding
Process(es)
positive regulation of immune system process immune response cell adhesion signal transduction cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of calcium ion transport into cytosol T cell differentiation macrophage differentiation leukocyte chemotaxis response to estradiol maintenance of protein location in cell positive regulation of interleukin-2 production response to vitamin D helper T cell enhancement of adaptive immune response interleukin-15-mediated signaling pathway positive regulation of T cell proliferation T cell activation T cell selection response to ethanol positive regulation of monocyte differentiation viral entry into host cell positive regulation of inflammatory response T cell receptor signaling pathway regulation of T cell activation positive regulation of multicellular organismal process cellular response to granulocyte macrophage colony-stimulating factor stimulus response to methamphetamine hydrochloride cellular response to ionomycin positive regulation of cytokine production immune system process humoral immune response positive regulation of gene expression negative regulation of gene expression T cell costimulation positive regulation of interleukin-10 production positive regulation of interleukin-4 production regulation of T cell proliferation negative regulation of apoptotic process regulatory T cell differentiation positive regulation of viral genome replication positive regulation of translation positive regulation of mitotic nuclear division positive regulation of T cell receptor signaling pathway positive regulation of T cell activation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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