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Invitrogen
Separase Monoclonal Antibody (XJ11-4D7)
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FIGURE: 1 / 1
Separase Antibody (MA1-16573) in ICC/IF
Immunocytochemistry analysis of Separase in HeLa cells. Samples were incubated with Separase monoclonal antibody (Product # MA1-16573). Overlay (blue) of centrosomal staining in HeLa cells. Centrosomal staining of separase (yellow), and gamma tubulin (green) in mitotic-metaphase cells and nuclear staining of separase in pre-mitotic cells.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA1-16573
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
XJ11-4D7
Immunogen
Maltose-Binding Protein fusion of C-terminal fragment of human Separase (amino acids 1866-1996).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: caspase-like protein ESPL1; Cut1/ESP1 related protein; cysteine protease; extra spindle pole bodies 1, separase; extra spindle pole bodies homolog 1; extra spindle poles like 1; extra spindle poles-like 1 protein; FLJ46492; KIAA0165; separase; separin, cysteine protease; unnamed protein product
Gene Aliases: Cerp; ESP1; PRCE; SEPA; SSE
UniProt ID: (Human) Q14674, (Mouse) P60330
Entrez Gene ID: (Human) 9700, (Mouse) 105988
mitotic sister chromatid segregation
nuclear division
mitotic cytokinesis
proteolysis
apoptotic process
maintenance of mitotic sister chromatid cohesion
maintenance of meiotic sister chromatid cohesion
establishment of mitotic spindle localization
positive regulation of mitotic metaphase/anaphase transition
negative regulation of sister chromatid cohesion
mitotic sister chromatid separation
meiotic chromosome separation
nuclear chromosome segregation
meiotic spindle organization
mitotic cell cycle
chromosome segregation
meiosis I
homologous chromosome segregation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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