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FIGURE: 1 / 9
Progranulin Antibody (MA1-187) in IHC
Immunohistochemistry analysis of progranulin was performed on human kidney tissue and is showing positive staining (left panel). To expose target proteins, antigen retrieval was performed by microwaving tissues for 15 minutes in 10mM sodium citrate buffer (pH 6.0). Tissue slides were probed with progranulin monoclonal antibody (Product # MA1-187) at a dilution of 1:20, over night at 4C in a humidified chamb... View More
Product Details
MA1-187
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
2D4-2F1
Immunogen
Recombinant human Progranulin
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
200 µg
Purification
Protein A
Storage buffer
PBS with 1mg/mL BSA, 30% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
By Western blot, MA1-187 detects Human Progranulin at ~85 kDa.
Target Information
Progranulin is the precursor protein of Granulin also called as Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature Granulin. Both Granulin and smaller cleavage product of Granulin regulates cell growth. Progranulin stimulates proliferation of many epithelial cells, promotes their anchorage-independent growth and, when overexpressed, confers epithelial tumorigenicity. Progranulin/epithelin gene is multifunctional, with important constitutive roles in epithelial homeostasis, reproductive, immunological, and neuronal function. Progranulin constitutively expressed in a number of epithelia, particularly in the skin, GI tract, and reproductive system. Progranulin is expressed in immune cells in vivo and in specific neurons in the brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Acrogranin; epithelin; Epithelin precursor; glycoprotein 88; Glycoprotein of 88 Kda; GP88; Granulin precursor; granulin-epithelin; granulins; PC cell-derived growth factor; PCDGF; PEPI; PGRN; Proepithelin; Progranulin; unnamed protein product
Gene Aliases: CLN11; FTD2; GEP; GP88; GRN; PCDGF; PEPI; PGRN
UniProt ID: (Human) P28799
Entrez Gene ID: (Human) 2896
trophectodermal cell proliferation
blastocyst hatching
astrocyte activation involved in immune response
microglial cell activation involved in immune response
lysosome organization
lysosomal transport
lysosomal lumen acidification
signal transduction
embryo implantation
positive regulation of cell proliferation
positive regulation of endothelial cell migration
positive regulation of cell migration
locomotory exploration behavior
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
positive regulation of angiogenesis
negative regulation of innate immune response
positive regulation of axon regeneration
epithelial cell proliferation
positive regulation of epithelial cell proliferation
regulation of inflammatory response
negative regulation of inflammatory response
regulation of developmental process
protein stabilization
positive regulation of cellular component organization
establishment of localization in cell
retina development in camera-type eye
negative regulation of respiratory burst involved in inflammatory response
maintenance of synapse structure
positive regulation of inflammatory response to wounding
positive regulation of defense response to bacterium
negative regulation of neutrophil activation
positive regulation of protein folding
negative regulation of microglial cell activation
positive regulation of trophectodermal cell proliferation
lysosomal protein catabolic process
positive regulation of aspartic-type peptidase activity
regulation of lysosome organization
positive regulation of lysosome organization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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