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Invitrogen

CGRP Monoclonal Antibody (4901)

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CGRP Monoclonal Antibody (4901)

Product Details

MA1-20209

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (IHC)

1:100
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-

ELISA (ELISA)

0.25-0.5 µg/mL
-

Neutralization (Neu)

Assay-dependent
-

Radioimmune Assays (RIA)

Assay-dependent
-
Product Specifications

Species Reactivity

Dog, Human, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

4901

Immunogen

Rat alpha-CGRP peptide. The epitope recognized by the antibody resides within the C-terminal ten amino acids of rat alpha-CGRP.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.1 mg/mL

Amount

105 µg

Purification

purified

Storage buffer

PBS, pH 7.4

Contains

15mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_557857

Product Specific Information

Recommended positive controls: rat alpha-CGRP.

MA1-20209 has been successfully used in ELISA, radioimmune assay, neutralizing, and immunocytochemistry procedures.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha-type CGRP; Calcitonin; calcitonin 1; calcitonin gene related protein; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin precursor; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; CGRP1; katacalcin; MGC126648; prepro-alpha-calcitonin gene-related peptide; RAT calcitonin; unnamed protein product

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Gene Aliases: Cal1; CAL6; CALC; CALC1; CALCA; calcitonin; CCALCI; CGRP; CGRP-alpha; CGRP-I; CGRP1; CT; KC; PCT; RATCAL6

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UniProt ID: (Dog) Q9MYV1, (Human) P06881, (Rat) P01256

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Entrez Gene ID: (Dog) 403946, (Human) 796, (Rat) 24241

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Function(s)
hormone activity receptor binding protein binding calcitonin receptor binding identical protein binding macromolecular complex binding receptor agonist activity neuropeptide hormone activity protein complex binding peptide hormone
Process(es)
signal transduction response to yeast endothelial cell proliferation vasculature development neurological system process involved in regulation of systemic arterial blood pressure G-protein coupled receptor internalization monocyte chemotaxis protein phosphorylation leukocyte cell-cell adhesion adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling embryo implantation regulation of blood pressure negative regulation of calcium ion transport into cytosol antibacterial humoral response antifungal humoral response receptor internalization activation of protein kinase activity positive regulation of interleukin-1 alpha production positive regulation of interleukin-8 production vasodilation endothelial cell migration innate immune response positive regulation of macrophage differentiation negative regulation of osteoclast differentiation negative regulation of blood pressure negative regulation of bone resorption negative regulation of transcription, DNA-templated negative regulation of smooth muscle contraction defense response to Gram-negative bacterium defense response to Gram-positive bacterium regulation of cytosolic calcium ion concentration antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to tumor necrosis factor calcitonin family receptor signaling pathway amylin receptor 1 signaling pathway amylin receptor 2 signaling pathway cellular response to nerve growth factor stimulus calcitonin gene-related peptide receptor signaling pathway vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure regulation of heart rate cellular calcium ion homeostasis inflammatory response neuropeptide signaling pathway neuromuscular junction development aging feeding behavior regulation of heart contraction response to heat negative regulation of ossification positive regulation of cAMP biosynthetic process negative regulation of neurological system process positive regulation of adenylate cyclase activity positive regulation of ossification positive regulation of cell adhesion positive regulation of vasodilation response to pain detection of temperature stimulus involved in sensory perception of pain positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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