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Invitrogen
PLA2R1 Monoclonal Antibody (12-6-5)
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FIGURE: 1 / 1
PLA2R1 Antibody (MA1-212) in IHC (P)
Immunohistochemistry was performed on human kidney tissue. Tissue was deparaffinized with xylene, followed by rehydration in sequential washes of 100% ethanol, 95% ethanol, 80% ethanol, and water. To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0) and heated for 20 min. Following antigen retrieval, tissues were blocked in a 10% goat serum (Product # 31872) in wash ... View More
Product Details
MA1-212
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
12-6-5
Immunogen
Human PLA2R1 extracellular sequence N-C3 (containing domains N-terminal Cysteine rich-FibII-CTLD1-CTLD2-CTLD3) amino acids 20-663 Recombinant protein expressed in HEK 293-EBNA-1 cells
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.2-7.4
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The immunogen is the Human PLA2R1 extracellular sequence N-C3 (containing domains N-terminal Cysteine rich-FibII-CTLD1-CTLD2-CTLD3) amino acids 20-663 Recombinant protein expressed in HEK 293-EBNA-1 cells
Target Information
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 180 kDa secretory phospholipase A2 receptor; C-type lectin domain family 13 member C; M-type receptor; phospholipase A2 receptor 1, 180kD; phospholipase A2 receptor 1, 180kDa; PLA2-R; putative soluble PLA2 receptor precursor; Secretory phospholipase A2 receptor
Gene Aliases: CLEC13C; PLA2-R; PLA2G1R; PLA2IR; PLA2R; PLA2R1
UniProt ID: (Human) Q13018
Entrez Gene ID: (Human) 22925
positive regulation of cytokine production
endocytosis
receptor-mediated endocytosis
positive regulation of DNA damage response, signal transduction by p53 class mediator
reactive oxygen species metabolic process
positive regulation of arachidonic acid secretion
replicative senescence
oxidative stress-induced premature senescence
negative regulation of arachidonic acid secretion
positive regulation of glomerular visceral epithelial cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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