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Invitrogen
HPV Type 16/18 E6 Monoclonal Antibody (C1P5)
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FIGURE: 1 / 1
HPV Type 16/18 E6 Antibody (MA1-46057) in WB
Scientific reports 2020 -
Figure 6 E7 protein expression in 293FT cells by overexpression of E7 mRNA having the endogenous structure. ( a , b ) Western blotting of E6 ( a ) and E7 protein ( b ) in 293FT cells (wild-type), 293FT cells transfected with pCAGIP-PA-E6/-PA-E7 or pCAGIP-endogenous E6/E7 mRNA, and UM104 cells. ( c ) E7 primers (# 645 and # 785) designed for binding within the E7 gene for use in qRT-PCR. ( d ) qRT-PCR analys... View More
Product Details
MA1-46057
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Virus
Published species
Virus
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
C1P5
Immunogen
Gel-purified HPV-18 E6-beta galactosidase fusion protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Human Papilloma virus (HPV) is responsible for the development of type and tissue specific papilloma in the oral cavity and in the larynx. In the skin papilloma virus can cause different types of warts and in the ano-genital region it is associated with condyloma or carcinoma. HPV types 1, 6 and 11 usually are associated with benign transformations of the tissues, while e.g. HPV types 16, 18 and 31 seem to be responsible for the development of some carcinoma like cervical carcinoma. The role of HPV in non-melanoic tumours of the skin is under discussion. Protein E6 is a Transcriptional transactivator, binding double stranded DNA. It has transforming activity inactivating, with E6-AP ubiquitin-protein ligase, the human TP53/p53 tumor suppressor protein by targeting it for degradation. Clinical relevance: Detection of HPV in cervical smears and biopsies. Uses: Analysis of E6 expression in cell transformation studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HPV-16; HPV-18; HPV16; HPV18; human papillomavirus
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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