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Invitrogen

Complement C3b Monoclonal Antibody (6C9)

2 Published Figures
6 References
View all (14) Complement C3b antibodies

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Product Details

MA1-70053

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

1 µg/1 million cells
View 2 publications 2 publications

ELISA (ELISA)

Assay-dependent
View 3 publications 3 publications

Functional Assay (Functional)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

6C9

Immunogen

Human C3.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

250 µg

Purification

Protein G

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1073823

Product Specific Information

MA1-70053 detects C3/C3b/iC3b in human and mouse samples.

MA1-70053 has been successfully used in flow cytometry and ELISA procedures.

The MA1-70053 immunogen is human C3.

Store at 4°C. For long term storage, aliquot and freeze unused portion at -20°C in volumes appropriat for single usage. Avoid freeze/thaw cycles.

Target Information

Inactive complement component 3b (iC3b) is a 42kDa neoantigen present in blood serum. Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, changes the structure and resulting binding properties, preventing binding by complement factor B and properdin. This prevents further progression of the complement pathway, providing another mechanism by which the complement pathway may be regulated. iC3b is thought to play a role in inducing tolerance, binding complement receptor type 3 on antigen presenting cells and stimulating them to produce transforming growth factor beta2 and interleukin-10. It is thought to stimulate B-cells via the CD21 receptor providing a link between the innate and adaptive immune responses. Additionally iC3b acts as an opsonin which is recognised by complement receptor 3 expressed on leukocytes or complement receptor of the immunoglobulin superfamily (CRIg) on Kupffer cells, stimulating phagocytosis of the tagged cells. iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosis and Rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: acylation stimulating protein; acylation-stimulating protein cleavage product; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a anaphylatoxin; complement 3; complement component 3; complement component 3d; complement component C3 precursor; complement component C3a; complement component C3b; complement factor 3; epididymis secretory sperm binding protein Li 62p; iC3b; prepro-C3; preprocomplement component C3; unnamed protein product

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Gene Aliases: AHUS5; ARMD9; ASP; C3a; C3b; CPAMD1; HEL-S-62p; HSE-MSF; Plp

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UniProt ID: (Mouse) P01027, (Human) P01024

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Entrez Gene ID: (Mouse) 12266, (Human) 718

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Function(s)
antigen binding endopeptidase inhibitor activity protein binding chemokine activity lipid binding C5L2 anaphylatoxin chemotactic receptor binding receptor agonist activity receptor binding
Process(es)
positive regulation of type IIa hypersensitivity complement activation, lectin pathway activation of membrane attack complex positive regulation of protein phosphorylation positive regulation of activation of membrane attack complex complement receptor mediated signaling pathway proteolysis inflammatory response complement activation complement activation, alternative pathway complement activation, classical pathway opsonization response to bacterium positive regulation of vascular endothelial growth factor production positive regulation of glucose transport regulation of triglyceride biosynthetic process positive regulation of lipid storage neuron remodeling regulation of complement activation regulation of complement activation, alternative pathway leukocyte chemotaxis killing of cells of other organism oviduct epithelium development vascular smooth muscle cell differentiation B cell activation positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of angiogenesis positive regulation of receptor-mediated endocytosis positive regulation of developmental growth positive regulation of phagocytosis protein maturation retina development in camera-type eye positive regulation of phagocytosis, engulfment positive regulation of ERK1 and ERK2 cascade positive regulation of glomerular mesangial cell proliferation beta-amyloid clearance complement-dependent cytotoxicity complement-mediated synapse pruning vertebrate eye-specific patterning complement activation, GZMK pathway positive regulation of opsonization positive regulation of sensory perception of pain negative regulation of vascular smooth muscle contraction positive regulation of apoptotic cell clearance immune response signal transduction G-protein coupled receptor signaling pathway positive regulation of immune response response to other organism
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