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Invitrogen
PLP1 Monoclonal Antibody (plpc1)
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FIGURE: 1 / 7
PLP1 Antibody (MA1-80034) in ICC/IF
Immunofluorescence analysis of PLP1 was performed using Hep G2 and MCF7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with PLP1 Monoclonal Antibody (plpc1) (Product # MA1-80034) at 1:100 dilution in 0.1% BSA and incubated overnight at 4 degree and then labeled with Goat anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32723, 1:2000 dilution... View More
Product Details
MA1-80034
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Human,
Mouse,
Non-human primate,
Rat
Published species
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
plpc1
Immunogen
Synthetic peptide GRGTKF corresponding to C terminal region of myelin proteolipid protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
<0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with all mammals based on sequence homology.
Mouse anti myelin proteolipid protein antibody, clone plpc1 recognizes myelin proteolipid protein (PLP) in many mammalian species (Stoffel et al. 1985).
Target Information
PLP1 is a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DM-20; Lipophilin; major myelin proteolipid protein; Myelin proteolipid protein; myelin synthesis deficiency; PLP; PLP1; proteolipid; proteolipid protein (myelin) 1; Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated); Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); rump shaker; unnamed protein product
Gene Aliases: DM20; GPM6C; HLD1; jimpy; jp; MMPL; msd; PLP; PLP/DM20; PLP1; PMD; rsh; SPG2
UniProt ID: (Bovine) P04116, (Dog) P23294, (Human) P60201, (Mouse) P60202, (Rat) P60203
Entrez Gene ID: (Bovine) 281410, (Dog) 481002, (Human) 5354, (Mouse) 18823, (Rat) 24943
inflammatory response
axon ensheathment
positive regulation of gene expression
astrocyte development
central nervous system myelination
myelination
long-chain fatty acid biosynthetic process
cell maturation
axon development
chemical synaptic transmission
substantia nigra development
integrin-mediated signaling pathway
glial cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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