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Invitrogen

pan Cadherin Monoclonal Antibody (CH-19)

Advanced Verification
13 Published Figures
8 References
View all (16) Pan-cadherin antibodies

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Product Details

MA1-91128

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
View 4 publications 4 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:500
-

Immunocytochemistry (ICC/IF)

1:500
View 3 publications 3 publications
Product Specifications

Species Reactivity

Amphibian, Bovine, Dog, Chicken, Cat, Guinea pig, Goat, Hamster, Human, Mouse, Sheep, Pig, Rabbit, Rodent, Reptile, Rat

Published species

Horse, Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

CH-19

Immunogen

Synthetic peptide corresponding to the C-terminal amino acids of chicken N-Cadherin with an extra N-terminal lysine residue (24 amino acids) coupled to KLH.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

6.1 mg/mL

Amount

610 µg

Storage buffer

Ascites

Contains

15mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1958717

Product Specific Information

Recommended positive controls: MDBK.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: cadherin 1, E-cadherin (epithelial); cadherin 1, type 1, E-cadherin (epithelial); cadherin 15, M-cadherin (myotubule); cadherin 15, type 1, M-cadherin (myotubule); cadherin 2, type 1 preproprotein; cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, P-cadherin (placental); cadherin 3, type 1, P-cadherin (placental); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin e; cadherin-E; Cadherin-N; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; calcium-dependent cell adhesion protein; CAM 120/80; CDH1; CDw325 antigen; cell-CAM 120/80; E-cadherin; E-cadherin 1; epididymis secretory sperm binding protein; Epithelial cadherin; L-CAM; liver cell adhesion molecule; liver cell adhesion protein; N-cadherin; N-cadherin 1; Neural cadherin; neural cadherin precursor; neural calcium-dependent cell adhesion molecule; Neural-cadherin; P-cadherin; Pan Cadherin; placental cadherin; Placental-cadherin; R-CAD; R-cadherin; retina cadherin; retinal cadherin; RPE-specific cadherin; unnamed protein product; uvomorulin

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Gene Aliases: ACOGS; ADHD8; ARC-1; ARVD14; BCDS1; CAD4; Cadherin-1; cadherin-2; Cadherin-3; cadherin-4; Cadp; CD324; CD325; CDH15; Cdh4l; CDHE; CDHN; CDHP; CDw325; E-cad; E-cadherin; ECAD; HJMD; I79_011330; I79_011331; I79_014914; K-CAM; L-CAM; LCAM; N-CAD; N-cadherin; NCAD; P-cadherin; PCAD; R-CAD; R-Cadh; RCAD; Um; UVO; Uvomorulin

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UniProt ID: (Human) P12830, (Chicken) P08641, (Bovine) Q6R8F2, (Dog) F1PAA9, (Human) P19022, (Chicken) P10288, (Bovine) P19535, (Human) P22223, (Human) P55283, (Chicken) P24503, (Rat) Q9R0T4, (Mouse) P09803, (Mouse) P15116, (Rat) Q9Z1Y3, (Mouse) P10287, (Mouse) P39038

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Entrez Gene ID: (Human) 999, (Chicken) 415860, (Bovine) 282637, (Dog) 442858, (Sheep) 101119747, (Pig) 100048953, (Goat) 102170451, (Rabbit) 100356548, (Bovine) 281062, (Sheep) 100170321, (Pig) 100515322, (Human) 1000, (Goat) 102188004, (Dog) 480169, (Chicken) 414745, (Rabbit) 100344571, (Goat) 102181807, (Dog) 611010, (Sheep) 101111652, (Chicken) 414845, (Bovine) 281063, (Rabbit) 100356285, (Pig) 100187727, (Human) 1001, (Human) 1002, (Pig) 100626354, (Sheep) 101122716, (Chicken) 419222, (Dog) 100685099, (Goat) 102173482, (Chinese hamster) 100758185, (Guinea pig) 100726210, (Rat) 83502, (Mouse) 12550, (Mouse) 12558, (Chinese hamster) 100689204, (Rat) 83501, (Chinese hamster) 100758473, (Guinea pig) 100725482, (Rat) 116777, (Mouse) 12560, (Guinea pig) 100720758, (Mouse) 12561, (Rat) 114588

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Function(s)
calcium ion binding protein binding beta-catenin binding ankyrin binding GTPase activating protein binding identical protein binding gamma-catenin binding cadherin binding cell adhesion molecule binding cell adhesion mediator activity protein tyrosine kinase binding RNA binding enzyme binding protein kinase binding protein phosphatase binding alpha-catenin binding extracellular matrix binding cytoskeletal protein binding protein domain specific binding binding, bridging protein binding involved in cell-cell adhesion macromolecular complex binding nitric-oxide synthase binding cadherin
Process(es)
cell morphogenesis desmosome assembly cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly response to xenobiotic stimulus response to toxic substance regulation of gene expression calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell migration pituitary gland development negative regulation of cell-cell adhesion negative regulation of cell migration negative regulation of axon extension neuron projection development cell junction assembly adherens junction organization positive regulation of protein import into nucleus cell-cell adhesion mediated by cadherin positive regulation of transcription, DNA-templated cellular response to lithium ion response to heparin cellular response to indole-3-methanol protein localization to plasma membrane cell-cell adhesion regulation of protein catabolic process at postsynapse, modulating synaptic transmission response to Gram-positive bacterium positive regulation of cellular protein localization cell-cell adhesion via plasma-membrane adhesion molecules regulation of signal transduction glial cell differentiation neuronal stem cell population maintenance type B pancreatic cell development neural crest cell development detection of muscle stretch positive regulation of axon extension synaptic vesicle clustering neuroligin clustering involved in postsynaptic membrane assembly regulation of postsynaptic density protein 95 clustering positive regulation of synaptic vesicle clustering cartilage condensation neural tube formation heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules brain development neural crest cell delamination positive regulation of MAPK cascade blood vessel morphogenesis brain morphogenesis homeostasis of number of cells regulation of axonogenesis striated muscle cell differentiation regulation of synaptic transmission, glutamatergic radial glial cell differentiation limb development neuroepithelial cell differentiation trigeminal ganglion formation trigeminal ganglion structural organization regulation of oligodendrocyte progenitor proliferation negative regulation of canonical Wnt signaling pathway cell aggregation retina homeostasis positive regulation of keratinocyte proliferation hair cycle process negative regulation of transforming growth factor beta receptor signaling pathway keratinization positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of melanin biosynthetic process hair follicle maturation negative regulation of catagen positive regulation of canonical Wnt signaling pathway in utero embryonic development trophectodermal cell differentiation epithelial cell morphogenesis embryo implantation sensory perception of sound negative regulation of protein processing positive regulation of cell-cell adhesion actin cytoskeleton organization regulation of protein localization uterine epithelium development decidualization negative regulation of epithelial cell proliferation intestinal epithelial cell development salivary gland cavitation regulation of branching involved in salivary gland morphogenesis establishment of skin barrier bicellular tight junction assembly cellular response to amino acid stimulus cochlea development negative regulation of protein localization to plasma membrane regulation of protein localization to cell surface regulation of neuron migration telencephalon development cerebral cortex development regulation of myelination regulation of Rho protein signal transduction modulation of synaptic transmission mesenchymal cell migration positive regulation of gene expression positive regulation of melanosome transport axon guidance
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