TGF beta-1,2,3 Monoclonal Antibody (1D11)

type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity enzyme binding type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding deubiquitinase activator activity identical protein binding protein serine/threonine kinase activator activity macromolecular complex binding antigen binding beta-amyloid binding receptor binding protein homodimerization activity transforming growth factor beta binding glycoprotein binding protein heterodimerization activity protein N-terminus binding receptor signaling protein serine/threonine kinase activity growth factor

negative regulation of transcription from RNA polymerase II promoter cell morphogenesis vasculogenesis ureteric bud development response to hypoxia morphogenesis of a branching structure cell activation epithelial to mesenchymal transition neural tube closure regulation of sodium ion transport sprouting angiogenesis chondrocyte differentiation columnar/cuboidal epithelial cell maturation hematopoietic progenitor cell differentiation connective tissue replacement involved in inflammatory response wound healing adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains tolerance induction to self antigen negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target heart valve morphogenesis aortic valve morphogenesis protein export from nucleus ATP biosynthetic process phosphate-containing compound metabolic process cellular calcium ion homeostasis apoptotic process inflammatory response transforming growth factor beta receptor signaling pathway Notch signaling pathway negative regulation of neuroblast proliferation salivary gland morphogenesis endoderm development heart development female pregnancy cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation germ cell migration response to xenobiotic stimulus response to wounding response to glucose gene expression regulation of gene expression positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of gene expression negative regulation of extracellular matrix disassembly positive regulation of epithelial to mesenchymal transition macrophage derived foam cell differentiation positive regulation of fibroblast migration negative regulation of macrophage cytokine production oligodendrocyte development positive regulation of microglia differentiation regulation of striated muscle tissue development neural tube development hyaluronan catabolic process T cell differentiation negative regulation of ossification negative regulation of cell growth osteoclast differentiation regulation of cell migration positive regulation of cell migration mammary gland development organ regeneration membrane protein intracellular domain proteolysis positive regulation of protein complex assembly positive regulation of exit from mitosis response to estradiol response to progesterone regulation of interleukin-23 production negative regulation of interleukin-17 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production receptor catabolic process positive regulation of superoxide anion generation mononuclear cell proliferation regulation of actin cytoskeleton organization positive regulation of collagen biosynthetic process response to vitamin D response to laminar fluid shear stress response to immobilization stress myofibroblast differentiation T cell proliferation T cell activation regulation of cell proliferation negative regulation of T cell proliferation regulation of protein import into nucleus positive regulation of protein import into nucleus odontogenesis of dentin-containing tooth positive regulation of odontogenesis myelination T cell homeostasis positive regulation of apoptotic process positive regulation of vascular permeability positive regulation of I-kappaB kinase/NF-kappaB signaling surfactant homeostasis proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration regulatory T cell differentiation cell-cell junction organization response to ethanol regulation of regulatory T cell differentiation positive regulation of regulatory T cell differentiation negative regulation of cell differentiation positive regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of myoblast differentiation positive regulation of epidermal growth factor receptor signaling pathway negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter muscle cell cellular homeostasis positive regulation of fibroblast proliferation lung alveolus development positive regulation of isotype switching to IgA isotypes lymph node development digestive tract development negative regulation of skeletal muscle tissue development positive regulation of smooth muscle cell proliferation inner ear development epithelial cell proliferation positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of protein secretion positive regulation of inflammatory response negative regulation of phagocytosis defense response to fungus negative regulation of T cell activation positive regulation of chemotaxis positive regulation of cellular component organization positive regulation of smooth muscle cell differentiation positive regulation of multicellular organismal process positive regulation of protein metabolic process negative regulation of release of sequestered calcium ion into cytosol neuron apoptotic process regulation of cell cycle positive regulation of cell division positive regulation of protein kinase B signaling ventricular cardiac muscle tissue morphogenesis phospholipid homeostasis canonical Wnt signaling pathway regulation of blood vessel remodeling face morphogenesis frontal suture morphogenesis positive regulation of SMAD protein import into nucleus bronchiole development mammary gland branching involved in thelarche branch elongation involved in mammary gland duct branching regulation of branching involved in mammary gland duct morphogenesis regulation of cartilage development retina vasculature development in camera-type eye connective tissue development Langerhans cell differentiation negative regulation of biomineral tissue development regulation of enamel mineralization lens fiber cell differentiation positive regulation of ERK1 and ERK2 cascade response to cholesterol cellular response to mechanical stimulus cellular response to glucose stimulus cellular response to growth factor stimulus cellular response to low-density lipoprotein particle stimulus cellular response to hypoxia cellular response to ionizing radiation cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus positive regulation of mononuclear cell migration odontoblast differentiation stem cell proliferation extracellular matrix assembly positive regulation of branching involved in ureteric bud morphogenesis positive regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway liver regeneration cellular response to virus transforming growth factor beta receptor superfamily signaling pathway negative regulation of hyaluronan biosynthetic process positive regulation of protein localization to nucleus positive regulation of extracellular matrix assembly response to salt positive regulation of mesenchymal stem cell proliferation regulation of miRNA transcription negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of protein localization to plasma membrane positive regulation of vasculature development positive regulation of STAT cascade regulation of epithelial to mesenchymal transition involved in endocardial cushion formation cellular response to acetaldehyde cellular response to insulin-like growth factor stimulus embryonic liver development negative regulation of cell-cell adhesion mediated by cadherin positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of endothelial cell apoptotic process positive regulation of primary miRNA processing positive regulation of stem cell proliferation positive regulation of cardiac muscle cell differentiation MAPK cascade negative regulation of protein phosphorylation positive regulation of protein phosphorylation protein phosphorylation cell cycle arrest mitotic cell cycle checkpoint epidermal growth factor receptor signaling pathway common-partner SMAD protein phosphorylation SMAD protein complex assembly positive regulation of peptidyl-threonine phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation cell migration regulation of transforming growth factor beta receptor signaling pathway negative regulation of cell-cell adhesion positive regulation of bone mineralization lipopolysaccharide-mediated signaling pathway positive regulation of cellular protein metabolic process positive regulation of peptidyl-serine phosphorylation positive regulation of mammary gland epithelial cell proliferation positive regulation of protein dephosphorylation positive regulation of MAP kinase activity protein kinase B signaling positive regulation of phosphatidylinositol 3-kinase activity ossification involved in bone remodeling negative regulation of mitotic cell cycle regulation of binding regulation of DNA binding pathway-restricted SMAD protein phosphorylation regulation of SMAD protein import into nucleus cellular response to organic cyclic compound positive regulation of NAD+ ADP-ribosyltransferase activity positive regulation of transdifferentiation positive regulation of transcription regulatory region DNA binding BMP signaling pathway positive regulation of luteinizing hormone secretion positive regulation of phosphorylation progesterone secretion positive regulation of follicle-stimulating hormone secretion regulation of protein secretion SMAD protein signal transduction eye development hair follicle development heart morphogenesis cell death glial cell migration cardioblast differentiation positive regulation of epithelial cell migration negative regulation of alkaline phosphatase activity positive regulation of phosphatidylinositol 3-kinase signaling signal transduction by protein phosphorylation collagen fibril organization positive regulation of cell growth activation of protein kinase activity positive regulation of stress-activated MAPK cascade regulation of transforming growth factor beta2 production positive regulation of cell adhesion mediated by integrin response to drug positive regulation of neuron apoptotic process positive regulation of integrin biosynthetic process positive regulation of ossification positive regulation of heart contraction embryonic digestive tract development positive regulation of catagen positive regulation of cardioblast differentiation cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition somitogenesis epithelial to mesenchymal transition involved in endocardial cushion formation negative regulation of cell adhesion nervous system development skeletal muscle tissue development gonad development male gonad development female gonad development response to virus embryo development ending in birth or egg hatching hemopoiesis lung development neutrophil chemotaxis regulation of growth wound healing endothelial cell activation dopamine biosynthetic process regulation of cell differentiation positive regulation of cell cycle somatic stem cell division animal organ development spleen development embryonic organ development neuron development positive regulation of immune response cartilage development response to growth hormone regulation of complement-dependent cytotoxicity skeletal system development cartilage condensation blood vessel development kidney development blood vessel remodeling outflow tract septum morphogenesis membranous septum morphogenesis outflow tract morphogenesis atrioventricular valve morphogenesis pulmonary valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis endocardial cushion fusion atrial septum primum morphogenesis neural retina development activation-induced cell death of T cells axon guidance sensory organ development striated muscle tissue development negative regulation of angiogenesis signaling extracellular matrix organization embryonic limb morphogenesis epithelial cell differentiation hair follicle morphogenesis ascending aorta morphogenesis odontogenesis uterine wall breakdown regulation of apoptotic process positive regulation of Notch signaling pathway negative regulation of Ras protein signal transduction neuron fate commitment generation of neurons regulation of timing of catagen uterus development ventricular septum morphogenesis atrial septum morphogenesis negative regulation of cartilage development pharyngeal arch artery morphogenesis secondary palate development positive regulation of cardiac epithelial to mesenchymal transition positive regulation of activation-induced cell death of T cells positive regulation of extracellular matrix disassembly extrinsic apoptotic signaling pathway in absence of ligand regulation of apoptotic process involved in outflow tract morphogenesis regulation of extracellular matrix organization substantia propria of cornea development pericyte cell differentiation cranial skeletal system development negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of extrinsic apoptotic signaling pathway in absence of ligand in utero embryonic development negative regulation of neuron apoptotic process positive regulation of filopodium assembly positive regulation of stress fiber assembly detection of hypoxia negative regulation of vascular smooth muscle cell proliferation positive regulation of occluding junction disassembly mesenchyme migration protein import into nucleus, translocation CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment defense response SMAD protein import into nucleus negative regulation of DNA replication defense response to fungus, incompatible interaction organ morphogenesis response to organic substance cell growth evasion or tolerance of host defenses by virus positive regulation of histone deacetylation regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of histone acetylation growth myeloid dendritic cell differentiation regulation of MAPK cascade cell development negative regulation of immune response positive regulation of NF-kappaB transcription factor activity negative regulation of gene silencing by miRNA positive regulation of cell cycle arrest T-helper 17 cell lineage commitment regulation of actin cytoskeleton reorganization cardiac left ventricle morphogenesis intracellular signal transduction catagen negative regulation of apoptotic process response to estrogen negative regulation of keratinocyte differentiation embryonic neurocranium morphogenesis activation of MAPK activity embryo development negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of DNA replication palate development