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Invitrogen
Vimentin Antibody Cocktail
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-14435
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mixed
/ IgG
Class
Cocktail
Type
Antibody
Clone
Vimentin-SP20, gp100-HMB45
Immunogen
Vimentin - recombinant protein encoding human Vimentin, gp100 - Extract of pigmented melanoma metastases from lymph nodes
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
purified
Storage buffer
proprietary buffer
Contains
<0.1% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-14435 targets Vimentin in IHC (P) applications and shows reactivity with Human samples.
The MA5-14435 immunogen is vimentin - recombinant protein encoding human Vimentin, gp100 - Extract of pigmented melanoma metastases from lymph nodes.
Host/Isotype: Rabbit/Mouse / IgG/IgG1, kappa
Target Information
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; FLJ36605; Hel113; RP11-124N14.1; unnamed protein product; VIM; VIME; vimentin
UniProt ID: (Human) P08670
Entrez Gene ID: (Human) 7431
positive regulation of gene expression
positive regulation of collagen biosynthetic process
regulation of mRNA stability
intermediate filament organization
positive regulation of axon extension
cellular response to lipopolysaccharide
cellular response to muramyl dipeptide
positive regulation of cellular protein localization
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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