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Invitrogen

Phospho-HDAC4/HDAC5/HDAC7 (Ser246, Ser259, Ser155) Monoclonal Antibody (B.544.8)

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Phospho-HDAC4/HDAC5/HDAC7 (Ser246, Ser259, Ser155) Monoclonal Antibody (B.544.8)

Product Details

MA5-14776

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

ChIP assay (ChIP)

1-3 µL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

B.544.8

Immunogen

Synthetic phosphopeptide corresponding to pSer155 of human HDAC7 protein
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980952

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Antigen NY-CO-9; HD4; HD5; HD7; HD7a; hdac-7; HDAC4; HDAC5; Histone deacetylase 4; Histone deacetylase 5; Histone deacetylase 7; Histone deacetylase 7A; histone deacetylase A; histone deacetylase mHDA1; Protein deacetylase HDAC7; putative Type II integral membrane protein; unnamed protein product

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Gene Aliases: 4932408F19Rik; 5830434K02Rik; AHO3; AI047285; AI426555; BDMR; HA6116; HD4; HD5; HD7; HD7A; HDAC-4; HDAC-A; HDAC4; HDAC5; HDAC7; HDAC7A; HDACA; KIAA0288; KIAA0600; mFLJ00062; mHDA1; mKIAA0600; NEDCHF; NEDCHID; NY-CO-9

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UniProt ID: (Human) P56524, (Human) Q9UQL6, (Human) Q8WUI4, (Mouse) Q6NZM9, (Mouse) Q8C2B3

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Entrez Gene ID: (Human) 9759, (Human) 10014, (Human) 51564, (Mouse) 208727, (Mouse) 15184, (Mouse) 56233

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding histone deacetylase activity protein binding zinc ion binding hydrolase activity SUMO transferase activity potassium ion binding protein deacetylase activity histone binding identical protein binding histone deacetylase binding metal ion binding binding, bridging RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding histone deacetylase activity, hydrolytic mechanism transcription corepressor binding chromatin binding protein kinase C binding transcription corepressor activity protein kinase binding 14-3-3 protein binding RNA polymerase III transcription factor binding core promoter binding DNA binding transcription factor binding histone deacetylase activity (H3-K14 specific) NAD-dependent histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) activating transcription factor binding histone deacetylase activity (H4-K16 specific) sequence-specific DNA binding transcription regulatory region DNA binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) repressing transcription factor binding NAD-dependent histone deacetylase activity (H3-K18 specific) core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding histone modifying enzyme
Process(es)
negative regulation of transcription from RNA polymerase II promoter chromatin organization chromatin remodeling protein deacetylation inflammatory response nervous system development positive regulation of cell proliferation negative regulation of macromolecule biosynthetic process negative regulation of myotube differentiation negative regulation of transcription by competitive promoter binding response to denervation involved in regulation of muscle adaptation cardiac muscle hypertrophy in response to stress protein sumoylation B cell differentiation positive regulation of protein sumoylation regulation of gene expression, epigenetic B cell activation negative regulation of gene expression, epigenetic negative regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter type I interferon signaling pathway response to interleukin-1 response to xenobiotic stimulus regulation of myotube differentiation response to activity neuron differentiation cellular response to insulin stimulus response to cocaine negative regulation of transcription, DNA-templated cellular response to lipopolysaccharide negative regulation of cell migration involved in sprouting angiogenesis vasculogenesis cell-cell junction assembly negative regulation of interleukin-2 production negative regulation of osteoblast differentiation regulation of mRNA processing positive regulation of cell migration involved in sprouting angiogenesis membraneless organelle assembly negative regulation of NIK/NF-kappaB signaling skeletal system development osteoblast development transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of cell proliferation positive regulation of lamellipodium assembly regulation of cardiac muscle contraction by calcium ion signaling positive regulation of smooth muscle cell migration chromatin modification histone deacetylation peptidyl-lysine deacetylation response to drug regulation of protein binding negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process positive regulation of smooth muscle cell proliferation regulation of skeletal muscle fiber development positive regulation of sequence-specific DNA binding transcription factor activity regulation of striated muscle cell differentiation histone H3 deacetylation histone H4 deacetylation positive regulation of reactive oxygen species biosynthetic process transcription from RNA polymerase II promoter heart development negative regulation of gene expression multicellular organismal response to stress negative regulation of striated muscle tissue development renal tubule morphogenesis cellular response to fluid shear stress positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation negative regulation of neuron death
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