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Invitrogen
JMJD2A Monoclonal Antibody (C.37.0)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-14782
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
C.37.0
Immunogen
Synthetic peptide corresponding to the human JMJD2A protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other Jumonji C proteins, including JMJD2B, JMJD2C and JMJD2D.
Target Information
JMJD2A is a member of the Jumonji domain 2 (JMJD2) family and a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; jmjC domain-containing histone demethylation protein 3A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; jumonji domain-containing protein 2A; lysine (K)-specific demethylase 4A; tudor domain containing 14A; unnamed protein product
Gene Aliases: D4Ertd222e; JHDM3A; JMJD2; JMJD2A; mKIAA0677; TDRD14A
UniProt ID: (Human) O75164, (Mouse) Q8BW72
Entrez Gene ID: (Human) 9682, (Mouse) 230674, (Rat) 313539
protein binding
zinc ion binding
ubiquitin protein ligase binding
histone demethylase activity
histone demethylase activity (H3-K9 specific)
histone demethylase activity (H3-K36 specific)
histone H4K20me2 reader activity
histone H3K36me2/H3K36me3 demethylase activity
histone H3K9me2/H3K9me3 demethylase activity
chromatin organization
chromatin remodeling
regulation of gene expression
negative regulation of autophagy
positive regulation of gene expression
negative regulation of gene expression
cardiac muscle hypertrophy in response to stress
apoptotic chromosome condensation
positive regulation of neuron differentiation
negative regulation of transcription, DNA-templated
negative regulation of astrocyte differentiation
response to nutrient levels
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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