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Invitrogen
LKB1 Monoclonal Antibody (E.425.6)
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FIGURE: 1 / 5
LKB1 Antibody (MA5-14831) in WB
Western blot was performed using Anti-LKB1 Monoclonal Antibody (E.425.6) (Product # MA5-14831) and a 55 kDa band corresponding to LKB1 was observed in all the tested cell models. Modified whole cell lysate (1% SDS) (30 µg lysate) of COS-7 (Lane 1), Caki-1 (Lane 2), K-562 (Lane 3), A-431 (Lane 4) and U-2 OS (Lane 5) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001).... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-14831
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
E.425.6
Immunogen
An LKB1 partial fusion protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
24 µg/mL
Amount
2.4 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
LKB1 (also known as STK11 - Serine/threonine-protein kinase STK11), a member of the serine/threonine kinase family, is a tumor suppressor. LKB1 physically associates with p53 and regulates specific p53 dependent apoptosis pathways. LKB1 is present in both the cytoplasm and nucleus of living cells and translocates to mitochondria during apoptosis. LKB1 functions as a master upstream protein kinase, regulating AMPK related kinases as well as AMPK. Mutations in LKB1 gene are associated with Peutz Jeghers syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAMK group; CAMKL family; liver kinase B1; liver kinase B1 homolog; LKB 1; LKB-1; LKB1(S); polarization-related protein LKB1; protein kinase; renal carcinoma antigen NY-REN-19; serine/threonine kinase 11; STK11; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1; unnamed protein product
Gene Aliases: hLKB1; LKB1; Par-4; PJS
UniProt ID: (Human) Q15831, (Mouse) Q9WTK7, (Rat) D4AE59
Entrez Gene ID: (Human) 6794, (Mouse) 20869, (Rat) 314621
regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
protein dephosphorylation
cellular response to DNA damage stimulus
signal transduction
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
peptidyl-threonine phosphorylation
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
response to lipid
cellular response to glucose starvation
glucose homeostasis
anoikis
positive thymic T cell selection
positive regulation of gluconeogenesis
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of axonogenesis
T cell receptor signaling pathway
Golgi localization
regulation of protein kinase B signaling
negative regulation of epithelial cell proliferation involved in prostate gland development
G1 to G0 transition
cellular response to UV-B
intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of canonical Wnt signaling pathway
dendrite extension
negative regulation of cold-induced thermogenesis
positive regulation of protein localization to nucleus
positive regulation of vesicle transport along microtubule
negative regulation of TORC1 signaling
response to activity
response to glucagon
response to peptide hormone
response to thyroid hormone
positive regulation of cellular senescence
regulation of cell cycle
regulation of signal transduction by p53 class mediator
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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