Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

PPAR gamma Monoclonal Antibody (K.242.9)

Advanced Verification
18 Published Figures
28 References
View all (34) PPAR gamma antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:

{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
PPAR gamma Monoclonal Antibody (K.242.9)

Product Details

MA5-14889

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 18 publications 18 publications

Immunohistochemistry (IHC)

-
View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:400-1:1,600
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:200
View 3 publications 3 publications

Immunoprecipitation (IP)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

K.242.9

Immunogen

Synthetic peptide corresponding to residues surrounding Asp69 of human PPAR-gamma
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

125 µg/mL

Amount

12.5 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10985650

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: HUMPPARG; ligand-activated nuclear transcription factor; ligand-activated transcription factor; nuclear receptor; nuclear receptor family member; Pparg; nuclear receptor subfamily 1 group C member 3; OTTHUMP00000185032; OTTHUMP00000185036; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor gamma 2; peroxisome proliferator activated receptor gamma 4; peroxisome proliferator-activated receptor-gamma 5; peroxisome proliferator-activated receptor-gamma splicing; PPAR gamma; PPAR-gamma; Pparg; PPARy; unnamed protein product

View more View less

Gene Aliases: CIMT1; FPLD3; GLM1; NR1C3; PPAR-gamma; PPAR-gamma2; PPARG1; PPARG2; PPARG5; PPARgamma; PPARgamma2

View more View less

UniProt ID: (Human) P37231, (Mouse) P37238

View more View less

Entrez Gene ID: (Human) 5468, (Mouse) 19016

View more View less

Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding prostaglandin receptor activity protein binding zinc ion binding enzyme binding peptide binding identical protein binding sequence-specific DNA binding retinoid X receptor binding arachidonic acid binding DBD domain binding LBD domain binding WW domain binding alpha-actinin binding R-SMAD binding E-box binding STAT family protein binding DNA-binding transcription factor binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcription coactivator binding protein phosphatase binding estrogen receptor binding promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter placenta development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter fatty acid metabolic process G-protein coupled receptor signaling pathway response to nutrient regulation of blood pressure hormone-mediated signaling pathway positive regulation of gene expression negative regulation of gene expression negative regulation of macrophage derived foam cell differentiation positive regulation of cholesterol efflux negative regulation of cholesterol storage negative regulation of lipid storage long-chain fatty acid transport negative regulation of angiogenesis cell differentiation monocyte differentiation BMP signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of BMP signaling pathway intracellular receptor signaling pathway epithelial cell differentiation response to nutrient levels positive regulation of cholesterol transport cellular response to insulin stimulus response to lipid peroxisome proliferator activated receptor signaling pathway glucose homeostasis regulation of circadian rhythm mRNA transcription from RNA polymerase II promoter negative regulation of MAPK cascade negative regulation of blood vessel endothelial cell migration innate immune response cell fate commitment fat cell differentiation positive regulation of fat cell differentiation negative regulation of osteoblast differentiation positive regulation of lipid metabolic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway cell maturation negative regulation of smooth muscle cell proliferation negative regulation of inflammatory response white fat cell differentiation brown fat cell differentiation regulation of transport negative regulation of multicellular organismal process lipid homeostasis negative regulation of interferon-gamma-mediated signaling pathway negative regulation of SMAD protein import into nucleus positive regulation of adiponectin secretion cellular response to low-density lipoprotein particle stimulus cellular response to hypoxia negative regulation of mitochondrial fission positive regulation of lipoprotein transport nuclear receptor-mediated signaling pathway beige fat cell differentiation regulation of cellular response to insulin stimulus negative regulation of extracellular matrix assembly negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of cardiac muscle hypertrophy in response to stress negative regulation of cellular response to transforming growth factor beta stimulus positive regulation of adipose tissue development negative regulation of connective tissue replacement involved in inflammatory response wound healing negative regulation of vascular smooth muscle cell proliferation negative regulation of receptor signaling pathway via STAT positive regulation of vascular associated smooth muscle cell apoptotic process negative regulation of vascular endothelial cell proliferation positive regulation of apoptotic signaling pathway negative regulation of cytokine production response to dietary excess diet induced thermogenesis wound healing involved in inflammatory response negative regulation of acute inflammatory response response to stress inflammatory response negative regulation of cell proliferation response to light stimulus regulation of gene expression negative regulation of smooth muscle cell migration regulation of lipid metabolic process fatty acid oxidation negative regulation of cell growth response to food cellular response to hormone stimulus negative regulation of collagen biosynthetic process cellular response to platelet-derived growth factor stimulus positive regulation of apoptotic process regulation of fat cell differentiation positive regulation of fatty acid oxidation regulation of hormone secretion positive regulation of oligodendrocyte differentiation positive regulation of phagocytosis, engulfment positive regulation of SMAD protein import into nucleus cellular response to lithium ion negative regulation of peptide hormone secretion cold-induced thermogenesis negative regulation of cellular response to insulin stimulus negative regulation of pancreatic stellate cell proliferation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support