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Phospho-AMPK alpha-1 (Ser485) Monoclonal Antibody (E.429.3)

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Phospho-AMPK alpha-1 (Ser485) Monoclonal Antibody (E.429.3)

Product Details

MA5-15019

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

E.429.3

Immunogen

Synthetic phosphopeptide corresponding to residues surrounding pSer485 of human AMPKa1
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

117 µg/mL

Amount

11.7 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10980450

Product Specific Information

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with phosphorylated AMPK-alpha2 or other related proteins.

Target Information

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AAPK2; ACACA kinase; acetyl-CoA carboxylase kinase; activated protein kinase; AMP -activate kinase alpha 1 subunit; AMP activated protein kinase; AMP-activated protein kinase, alpha 1 catalytic subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK alpha-1 chain; AMPK subunit alpha-1; AMPK subunit pAMPK; AMPK, alpha, 1; AMPK-alpha-2 chain; AMPK2; HMGCR kinase; hydroxymethylglutaryl-CoA reductase kinase; MGC33776; MGC57364; pAMPK; PRKAA; PRKAA2; protein kinase, AMP-activated, alpha 1 catalytic subunit; tau-protein kinase PRKAA1; unnamed protein product

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Gene Aliases: AMPK; AMPK alpha 1; AMPKa1; AMPKalpha1; C130083N04Rik

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UniProt ID: (Human) Q13131, (Rat) P54645, (Mouse) Q5EG47

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Entrez Gene ID: (Human) 5562, (Rat) 65248, (Mouse) 105787

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Function(s)
chromatin binding protein kinase activity protein serine/threonine kinase activity AMP-activated protein kinase activity cAMP-dependent protein kinase activity protein binding ATP binding macromolecular complex binding [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity tau protein binding tau-protein kinase activity protein serine kinase activity histone H2BS36 kinase activity eukaryotic elongation factor-2 kinase activator activity kinase binding
Process(es)
positive regulation of T cell mediated immune response to tumor cell glucose metabolic process chromatin remodeling protein phosphorylation positive regulation of cell proliferation lipid biosynthetic process cellular response to starvation response to xenobiotic stimulus response to UV cold acclimation response to gamma radiation positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression response to activity negative regulation of translation fatty acid oxidation response to caffeine cellular response to nutrient levels negative regulation of TOR signaling regulation of peptidyl-serine phosphorylation cellular response to stress cellular response to oxidative stress cellular response to glucose starvation response to hydrogen peroxide glucose homeostasis regulation of circadian rhythm negative regulation of apoptotic process regulation of vascular permeability response to estrogen positive regulation of gluconeogenesis positive regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of fatty acid oxidation positive regulation of glucose import negative regulation of insulin receptor signaling pathway positive regulation of skeletal muscle tissue development positive regulation of T cell activation negative regulation of lipid catabolic process fatty acid homeostasis regulation of vesicle-mediated transport motor behavior CAMKK-AMPK signaling cascade regulation of stress granule assembly neuron cellular homeostasis cellular response to hydrogen peroxide regulation of microtubule cytoskeleton organization cellular response to calcium ion cellular response to glucose stimulus cellular response to ethanol cellular response to prostaglandin E stimulus cellular response to hypoxia cellular response to xenobiotic stimulus protein localization to membrane protein localization to plasma membrane energy homeostasis negative regulation of ferroptosis positive regulation of transcription from mitochondrial promoter positive regulation of establishment of protein localization to mitochondrion positive regulation of cellular protein localization negative regulation of hepatocyte apoptotic process positive regulation of adipose tissue development negative regulation of TORC1 signaling lipid droplet disassembly protein localization to lipid particle autophagosome assembly cytoplasmic translation negative regulation of T cell mediated immune response to tumor cell phosphatidylethanolamine biosynthetic process phosphatidylcholine biosynthetic process autophagy lysosome organization positive regulation of catabolic process SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein destabilization cellular response to amino acid starvation TORC1 signaling proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of translational initiation positive regulation of translational initiation protein stabilization negative regulation of T cell activation protein localization to lysosome protein-containing complex assembly protein K6-linked ubiquitination positive regulation of release of cytochrome c from mitochondria hepatocyte apoptotic process negative regulation of protein localization to nucleus positive regulation of TORC1 signaling response to hypoxia signal transduction positive regulation of cholesterol biosynthetic process negative regulation of glucosylceramide biosynthetic process
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