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Invitrogen
GEF-H1 Monoclonal Antibody (K.607.1)
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Product Details
MA5-15027
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Hamster,
Human,
Mouse,
Non-human primate,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
K.607.1
Immunogen
Synthetic peptide corresponding to the sequence of human GEF-H1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
33 µg/mL
Amount
3.3 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
GEF-H1 activates Rho GTPases by promoting the exchange of GDP and GTP. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. GEF-H1 may be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp547L106; DKFZp547P1516; FLJ45440; GEF-H1; guanine nucleotide exchange factor H1; LBC'S first cousin; lymphoid blast crisis-like 1; microtubule-regulated Rho-GEF; oncogene LFC; OTTHUMP00000018855; proliferating cell nucleolar antigen p40; Rho guanine nucleotide exchange factor 2; rho guanine nucleotide exchange factor 2-like protein; Rho/Rac guanine nucleotide exchange factor (GEF) 2; rhobin; unnamed protein product
Gene Aliases: GEF; GEF-H1; GEFH1; Lbcl1; Lfc; LFP40; mKIAA0651; NEDMHM; P40
UniProt ID: (Human) Q92974, (Mouse) Q60875, (Rat) Q5FVC2
Entrez Gene ID: (Human) 9181, (Chinese hamster) 100758849, (Mouse) 16800, (Rat) 310635
establishment of mitotic spindle orientation
cell morphogenesis
intracellular protein transport
actin filament organization
negative regulation of microtubule depolymerization
small GTPase mediated signal transduction
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
regulation of Rho protein signal transduction
regulation of cell proliferation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of neurogenesis
regulation of small GTPase mediated signal transduction
asymmetric neuroblast division
negative regulation of necroptotic process
cellular response to muramyl dipeptide
cellular response to tumor necrosis factor
cellular hyperosmotic response
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
positive regulation of neuron migration
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of podosome assembly
tumor necrosis factor-mediated signaling pathway
positive regulation of Rac protein signal transduction
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of ERK1 and ERK2 cascade
positive regulation of wound healing
positive regulation of p38MAPK cascade
positive regulation of metalloendopeptidase activity
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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