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Invitrogen
Nonphospho-4EBP1 (Thr46) Monoclonal Antibody (E.638.3)
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FIGURE: 1 / 2
Nonphospho-4EBP1 (Thr46) Antibody (MA5-15032) in WB
Western blot analysis of Nonphospho-4E-BP1 (Thr46) in extracts from COS cells, treated with lambda phosphatase or 20% FBS, using Nonphospho-4E-BP1 (Thr46) monoclonal antibody (Product # MA5-15032) (upper), Phospho-4E-BP1 (Thr37/46) antibody (middle), and 4E-BP1 antibody (lower).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15032
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
E.638.3
Immunogen
Synthetic peptide corresponding to residues surrounding Thr46 of human 4E-BP1
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
138 µg/mL
Amount
13.8 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E, which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4E-BP1; eIF4E-binding protein 1; EIF4EBP1; MGC431; MGC4316; P/OKCL.6; PHAS-1; phosphorylated heat- and acid-stable protein regulated by insulin 1; unnamed protein product
Gene Aliases: 4E-BP1; 4EBP1; BP-1; PHAS-I
UniProt ID: (Human) Q13541, (Mouse) Q60876, (Rat) Q62622
Entrez Gene ID: (Human) 1978, (Mouse) 13685, (Rat) 116636
G1/S transition of mitotic cell cycle
IRES-dependent translational initiation
regulation of translational initiation
insulin receptor signaling pathway
negative regulation of translation
negative regulation of protein complex assembly
TOR signaling
positive regulation of mitotic cell cycle
negative regulation of translational initiation
cellular response to hypoxia
cellular response to dexamethasone stimulus
response to amino acid starvation
response to ischemia
lung development
response to ethanol
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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