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Invitrogen
Bcl-W Monoclonal Antibody (F.584.7)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15076
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
F.584.7
Immunogen
Synthetic peptide corresponding to residues surrounding alanine 39 of Bcl-w
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
107 µg/mL
Amount
10.7 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Using a PCR-based strategy, an additional protein with life-promoting activity, designated Bcl-w, has been identified. The protein is highly conserved between mouse and human and is encoded by a gene located near the TCRalpha gene on chromosome 14. Bcl-w is expressed in myeloid cell lines but not in T and B lymphocytes, and can be found in a wide range of tissues. An alternative splicing event in exon 4 results in two transcripts. The first, Bcl-w, encodes a protein of 193 amino acids, and the second, Bcl-w/rox, encodes a protein 333 amino acids in length. The "rox" portion of Bcl-w/rox shows a striking 66% amino acid sequence identity with the Drosophila rox2 protein; however, the Bcl-w/rox transcript may be expressed at very low levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: apoptosis regulator BCL-W; Bcl-2 family member; BCL2-like 2 protein; Bcl2-like protein 2; c98; KIAA0271; protein phosphatase 1, regulatory subunit 51; unnamed protein product
Gene Aliases: BCL-W; BCL-WEL; BCL-WS; BCL2-L-2; BCLW; c98; Gtrgal2; Gtrosa41; PPP1R51
UniProt ID: (Human) Q92843, (Mouse) P70345
Entrez Gene ID: (Human) 599, (Mouse) 12050, (Rat) 60434
release of cytochrome c from mitochondria
gonad development
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of mitochondrial membrane permeability
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
transmembrane transport
Sertoli cell proliferation
negative regulation of release of cytochrome c from mitochondria
extrinsic apoptotic signaling pathway in absence of ligand
developmental process involved in reproduction
spermatogenesis
response to ischemia
apoptotic process
cellular response to amino acid stimulus
cellular response to estradiol stimulus
cellular response to beta-amyloid
cellular response to glycine
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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