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Invitrogen
Phospho-ErbB3 (Tyr1289) Monoclonal Antibody (E.350.3)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15166
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
E.350.3
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding pTyr1289 of human HER3/ErbB3
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
113 µg/mL
Amount
11.3 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is over-expressed in a variety of tumors in the prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents. The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and is transcribed into a 6. 2kb mRNA which is translated into a 160/180 kDa glycoprotein. The ErbB3 gene encodes a transmembrane receptor tyrosine kinase due to alternative splicing and forms heterodimers with other EGF receptor family members that have kinase activity. Heterodimerization leads to the activation of pathways that lead to cell proliferation or differentiation. Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized. One ErbB3 isoform lacks the intermembrane region, is secreted outside the cell, and acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: avian erythroblastosis oncogene B 3 receptor; c-erbB-3; C-errB-3; epidermal growth factor receptor precursor; erbB3; glial growth factor receptor; HER3 protein precursor; human epidermal growth factor receptor 3; MDA BF 1; MGC88033; p180 ErbB3; p45 sErbB3; p85 sErbB3; proto-oncogene-like protein c-ErbB-3; receptor tyrosine kinase; tyrosine kinase-type cell surface receptor HER3; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3
Gene Aliases: c-erbB-3; c-erbB3; ErbB-3; erbB3-S; Erbb3r; FERLK; HER3; LCCS2; MDA-BF-1; p180-ErbB3; p45-sErbB3; p85-sErbB3; VSCN1
UniProt ID: (Human) P21860, (Mouse) Q61526
Entrez Gene ID: (Human) 2065, (Mouse) 13867
protein kinase activity
protein tyrosine kinase activity
transmembrane signaling receptor activity
protein binding
ATP binding
growth factor binding
protein tyrosine kinase activator activity
ubiquitin protein ligase binding
signaling receptor activity
neuregulin receptor activity
neuregulin binding
identical protein binding
ErbB-3 class receptor binding
protein heterodimerization activity
transmembrane receptor protein tyrosine kinase activity
negative regulation of cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
peripheral nervous system development
heart development
neuromuscular junction development
negative regulation of signal transduction
Schwann cell differentiation
Schwann cell development
cranial nerve development
neuron differentiation
ERBB signaling pathway
ERBB2-ERBB3 signaling pathway
wound healing
regulation of cell proliferation
myelination
negative regulation of apoptotic process
positive regulation of MAPK cascade
protein kinase B signaling
negative regulation of neuron apoptotic process
positive regulation of JNK cascade
positive regulation of epithelial cell proliferation
negative regulation of secretion
neuron apoptotic process
positive regulation of protein kinase B signaling
extrinsic apoptotic signaling pathway in absence of ligand
endocardial cushion development
nervous system development
positive regulation of gene expression
ERBB2 signaling pathway
positive regulation of glucose import
animal organ development
positive regulation of cardiac muscle tissue development
positive regulation of calcineurin-NFAT signaling cascade
positive regulation of membrane permeability
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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