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Invitrogen
MAP2K4 Monoclonal Antibody (2D10D8, 4G11B2, 2D10C4, 2D10C3)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15308
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
2D10D8, 4G11B2, 2D10C4, 2D10C3
Immunogen
Purified recombinant fragment of MAP2K4 expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15308 targets MAP2K4 in indirect ELISA, IHC applications and shows reactivity with Human samples.
The MA5-15308 immunogen is purified recombinant fragment of MAP2K4 expressed in E. Coli.
Target Information
MAP2K4 (MEK4) serine/threonine kinase (mitogen-activated protein kinase 4) MEK4 or MKK4 is a dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38. MAP2K4 preferentially phosphorylates the tyrosine residue of JNKs. MAP2K4 mediates a variety of physiological and pathophysiological processes such as responses to cellular stresses and inflammatory cytokines. MAP2K4 is important for carcinogenesis; a loss-off-function mutation in MAP2K4 was found in lung and pancreatic tumors. Conversely, a pro-oncogenic role was also found for MAP2K4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: c-Jun N-terminal kinase kinase 1; c-Jun NH2-terminal kinase kinase 1; JNK-activated kinase 1; JNK-activating kinase 1; MAP kinase kinase 4; MAP2K4; MAPK/ERK kinase 4; MAPKK 4; MEK 4; SAPK/ERK kinase 1; stress-activated protein kinase kinase 1; unnamed protein product
Gene Aliases: JNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1
UniProt ID: (Human) P45985
Entrez Gene ID: (Human) 6416
MAPK cascade
signal transduction
cell surface receptor signaling pathway
JNK cascade
neuromuscular junction development
cellular response to stress
smooth muscle cell apoptotic process
intrinsic apoptotic signaling pathway in response to hydrogen peroxide
Fc-epsilon receptor signaling pathway
ERBB signaling pathway
cellular response to mechanical stimulus
cellular senescence
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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