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Invitrogen
EphA4 Monoclonal Antibody (7D3D4)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15414
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
7D3D4
Immunogen
Purified recombinant fragment of EphA4 (aa777-986) expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15414 targets EphA4 in indirect ELISA, WB applications and shows reactivity with Human samples.
The MA5-15414 immunogen is purified recombinant fragment of EphA4 (aa777-986) expressed in E. Coli.
.
Target Information
EPHA4 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EphA4 encodes a protein that binds ephrin-A ligands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epa4; EPH-like kinase 8; receptor protein-tyrosine kinase HEK8; TYRO1 protein tyrosine kinase; tyrosine-protein kinase receptor SEK; tyrosine-protein kinase TYRO1; unnamed protein product
Gene Aliases: EK8; HEK8; SEK; TYRO1
UniProt ID: (Human) P54764
Entrez Gene ID: (Human) 2043
beta-amyloid binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity
protein binding
ATP binding
kinase activity
PH domain binding
identical protein binding
ephrin receptor binding
DH domain binding
protein tyrosine kinase binding
negative regulation of cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
axon guidance
motor neuron axon guidance
positive regulation of cell proliferation
glial cell migration
negative regulation of epithelial to mesenchymal transition
negative regulation of neuron projection development
negative regulation of translation
corticospinal tract morphogenesis
positive regulation of cell migration
negative regulation of cell migration
adherens junction organization
regulation of GTPase activity
positive regulation of cell adhesion
positive regulation of JNK cascade
ephrin receptor signaling pathway
negative regulation of axon regeneration
regulation of astrocyte differentiation
regulation of axonogenesis
positive regulation of dendrite morphogenesis
protein stabilization
regulation of dendritic spine morphogenesis
negative regulation of ERK1 and ERK2 cascade
cochlea development
fasciculation of sensory neuron axon
fasciculation of motor neuron axon
neuron projection guidance
synapse pruning
neuron projection fasciculation
negative regulation of cellular response to hypoxia
negative regulation of long-term synaptic potentiation
positive regulation of beta-amyloid formation
positive regulation of intracellular signal transduction
positive regulation of amyloid precursor protein catabolic process
cellular response to beta-amyloid
positive regulation of leukocyte adhesion to arterial endothelial cell
regulation of modification of synaptic structure
regulation of synapse pruning
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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