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Invitrogen

FOXA2 Monoclonal Antibody (7H4B7)

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View all (30) FOXA2 antibodies

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Product Details

MA5-15542

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

7H4B7

Immunogen

Purified recombinant fragment of FOXA2 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. not determined

Storage buffer

ascites

Contains

0.03% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10979228

Product Specific Information

MA5-15542 targets FOXA2 in indirect ELISA, IHC and WB applications and shows reactivity with Human samples.

The MA5-15542 immunogen is purified recombinant fragment of FOXA2 expressed in E. Coli.

MA5-15542 detects FOXA2 which has a predicted molecular weight of approximately 48kDa.

Target Information

FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: FKHL20; Forkhead box protein A2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3 beta (winged helix transcription factor); Hepatocyte nuclear factor 3-beta; HNF-3-beta; MGC19807; RONU; TCF-3B; Transcription factor 3B; unnamed protein product; WHN

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Gene Aliases: FOXA2; HNF-3-beta; Hnf-3b; HNF3-beta; HNF3B; HNF3beta; Tcf-3b; TCF3B

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UniProt ID: (Human) Q9Y261, (Mouse) A2AR89

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Entrez Gene ID: (Human) 3170, (Mouse) 15376

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding protein domain specific binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding double-stranded DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor binding kinase binding transcription regulatory region DNA binding SMAD binding winged helix/forkhead transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell fate specification chromatin organization regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter adult locomotory behavior anatomical structure morphogenesis negative regulation of epithelial to mesenchymal transition cell differentiation regulation of blood coagulation endocrine pancreas development positive regulation of embryonic development positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of insulin secretion involved in cellular response to glucose stimulus response to interleukin-6 dopaminergic neuron differentiation primitive streak formation positive regulation of cell-cell adhesion mediated by cadherin positive regulation of gastrulation positive regulation of transcription from RNA polymerase II promoter by glucose negative regulation of transcription from RNA polymerase II promoter by glucose in utero embryonic development ectoderm formation transcription, DNA-templated transcription from RNA polymerase II promoter Notch signaling pathway multicellular organism development pattern specification process anterior/posterior pattern specification dorsal/ventral pattern formation regulation of gene expression chromatin modification regulation of lipid metabolic process regulation of steroid metabolic process cell differentiation in hindbrain dorsal/ventral neural tube patterning signal transduction involved in regulation of gene expression lung development somite rostral/caudal axis specification negative regulation of glucokinase activity negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of smoothened signaling pathway positive regulation of transcription from RNA polymerase III promoter cell development anatomical structure formation involved in morphogenesis neuron fate specification epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation connective tissue development negative regulation of detection of glucose
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