Search
Invitrogen
Ku80 Monoclonal Antibody (5C5)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15873
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
5C5
Immunogen
Purified recombinant fragment of human XRCC5 expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15873 targets XRCC5 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human and mouse samples.
The MA5-15873 immunogen is purified recombinant fragment of human XRCC5 expressed in E. Coli. .
MA5-15873 detects XRCC5 which has a predicted molecular weight of approximately 86kDa.
Target Information
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; FLJ39089; HGNC:12833; Ku (p70/p80) subunit; Ku antigen; ku autoantigen protein p86 homolog; Ku autoantigen, 80kDa; Ku-80; Ku-86; Ku86 autoantigen related protein 1; Lupu; lupus; lupus Ku autoantigen protein p86; nuclear factor IV; OTTHUMP00000164061; OTTHUMP00000206791; thyroid-lupus autoantigen; TLAA; unnamed protein product; X-ray repair complementing defective repair in Chinese hamster cells 5; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair cross-complementing protein 5
Gene Aliases: CTC85; CTCBF; KARP-1; KARP1; KU80; Ku86; KUB2; Kup80; NFIV
UniProt ID: (Human) P13010, (Mouse) P27641
Entrez Gene ID: (Human) 7520, (Mouse) 22596
transcription regulatory region sequence-specific DNA binding
DNA binding
DNA helicase activity
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
RNA binding
protein binding
enzyme activator activity
DNA-dependent ATPase activity
ATPase activity
ubiquitin protein ligase binding
U3 snoRNA binding
telomeric DNA binding
3'-5' DNA helicase activity
macromolecular complex binding
DNA end binding
5'-deoxyribose-5-phosphate lyase activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
telomere maintenance
recombinational repair
activation of innate immune response
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
telomere maintenance via telomerase
cell proliferation
small-subunit processome assembly
negative regulation of transcription, DNA-templated
regulation of smooth muscle cell proliferation
positive regulation of neurogenesis
hematopoietic stem cell differentiation
protein localization to chromosome, telomeric region
cellular hyperosmotic salinity response
cellular response to gamma radiation
cellular response to X-ray
negative regulation of t-circle formation
cellular response to leukemia inhibitory factor
regulation of telomere maintenance
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support