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Invitrogen
BMI-1 Monoclonal Antibody (3E3)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-15919
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3E3
Immunogen
Purified recombinant fragment of human BMI1 expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-15919 targets BMI1 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human samples.
The MA5-15919 immunogen is purified recombinant fragment of human BMI1 expressed in E. Coli. .
MA5-15919 detects BMI1 which has a predicted molecular weight of approximately 37kDa.
Target Information
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B lymphoma Mo-MLV insertion region 1; B lymphoma Mo-MLV insertion region 1 homolog; bmi-1; BMI1 polycomb ring finger oncogene; BMI1 polycomb ring finger proto-oncogene; Bmi1 polycomb ring finger protot-oncogene; COMMD3; murine leukemia viral (bmi-1) oncogene homolog; Pcgf4 antibody; polycomb group protein Bmi1; polycomb group ring finger 4; polycomb group RING finger protein 4; protein-binding protein; BMI1; putative; ring finger protein 51; RP11-573G6.1; unnamed protein product
Gene Aliases: Bmi-1; flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51
UniProt ID: (Human) P35226, (Mouse) P25916
Entrez Gene ID: (Human) 648, (Mouse) 12151
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
in utero embryonic development
chromatin organization
chromatin remodeling
methylation-dependent chromatin silencing
humoral immune response
brain development
regulation of gene expression
rostrocaudal neural tube patterning
hemopoiesis
positive regulation of B cell proliferation
positive regulation of immature T cell proliferation in thymus
negative regulation of gene expression, epigenetic
somatic stem cell division
positive regulation of fibroblast proliferation
embryonic skeletal system morphogenesis
embryonic skeletal system development
positive regulation of ubiquitin-protein transferase activity
hematopoietic stem cell homeostasis
regulation of adaxial/abaxial pattern formation
negative regulation of apoptotic signaling pathway
segment specification
heterochromatin assembly
negative regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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