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Invitrogen

TLR2 Monoclonal Antibody (TL2.1)

5 Published Figures
6 References
View all (73) TLR2 antibodies

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TLR2 Monoclonal Antibody (TL2.1)

Product Details

MA5-16200

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:10-1:500
View 1 publication 1 publication

Flow Cytometry (Flow)

1 µg/10^6 cells
View 2 publications 2 publications

Immunoprecipitation (IP)

2-5 µg
-

Neutralization (Neu)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Dog, Human, Mouse, Rabbit, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

TL2.1

Immunogen

CHO cells transfected with human TLR2 cDNA.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2537718

Product Specific Information

Suggested positive control: antigen standard for TLR2 (transient overexpression lysate), PBMCs, Ramos.

Target Information

TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD282; extracellular domain; TIL4; TLR-2; Toll-like receptor 2; toll-like receptor 2 variant 1; toll-like receptor 2 variant 2; Toll/interleukin-1 receptor-like protein 4; unnamed protein product

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Gene Aliases: CD282; Ly105; TIL4; TLR2

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UniProt ID: (Human) O60603, (Mouse) Q9QUN7

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Entrez Gene ID: (Human) 7097, (Dog) 448807, (Rabbit) 100009578, (Rat) 310553, (Mouse) 24088

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Function(s)
lipopolysaccharide binding beta-amyloid binding lipopolysaccharide receptor activity transmembrane signaling receptor activity protein binding Toll-like receptor binding signaling receptor activity pattern recognition receptor activity triacyl lipopeptide binding identical protein binding peptidoglycan binding macromolecular complex binding NAD+ nucleotidase, cyclic ADP-ribose generating NAD(P)+ nucleosidase activity receptor activity signaling pattern recognition receptor activity diacyl lipopeptide binding protein heterodimerization activity lipoteichoic acid binding lipopeptide binding
Process(es)
toll-like receptor signaling pathway immune system process apoptotic process inflammatory response immune response signal transduction learning positive regulation of gene expression microglia development positive regulation of Wnt signaling pathway lipopolysaccharide-mediated signaling pathway positive regulation of chemokine production positive regulation of interferon-beta production positive regulation of interleukin-12 production positive regulation of interleukin-18 production positive regulation of interleukin-6 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production toll-like receptor 2 signaling pathway toll-like receptor TLR6:TLR2 signaling pathway detection of triacyl bacterial lipopeptide detection of diacyl bacterial lipopeptide positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response positive regulation of transcription from RNA polymerase II promoter positive regulation of inflammatory response negative regulation of phagocytosis defense response to Gram-positive bacterium positive regulation of NF-kappaB transcription factor activity defense response to virus negative regulation of synapse assembly cellular response to bacterial lipopeptide cellular response to lipoteichoic acid cellular response to interferon-gamma cellular response to diacyl bacterial lipopeptide cellular response to triacyl bacterial lipopeptide positive regulation of cellular response to macrophage colony-stimulating factor stimulus positive regulation of matrix metallopeptidase secretion response to hypoxia microglial cell activation response to molecule of fungal origin positive regulation of leukocyte migration cell surface pattern recognition receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway leukotriene metabolic process I-kappaB phosphorylation negative regulation of cell proliferation response to bacterium response to toxic substance central nervous system myelin formation response to bacterial lipoprotein response to peptidoglycan response to lipopolysaccharide response to progesterone negative regulation of interleukin-12 production negative regulation of interleukin-17 production positive regulation of interleukin-10 production response to insulin positive regulation of toll-like receptor signaling pathway positive regulation of NF-kappaB import into nucleus positive regulation of tumor necrosis factor biosynthetic process chloramphenicol transport negative regulation of growth of symbiont in host positive regulation of nitric oxide biosynthetic process nitric oxide metabolic process positive regulation of oligodendrocyte differentiation positive regulation of cytokine secretion positive regulation of nitric-oxide synthase biosynthetic process induction by symbiont of defense-related host nitric oxide production positive regulation of macrophage cytokine production response to fatty acid cellular response to peptidoglycan regulation of cytokine secretion response to molecule of bacterial origin cytokine secretion involved in immune response regulation of dendritic cell cytokine production interleukin-10 production
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