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Invitrogen
ErbB2 (HER-2) Recombinant Rabbit Monoclonal Antibody (SP3)
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FIGURE: 1 / 3
ErbB2 (HER-2) Antibody (MA5-16348) in IHC
The Journal of pathology 2024 -
4 Figure Field clonalization can precede DCIS formation. (A) Schematic overview of all 16 samples, the presence of shared aberrations in the pathologically healthy tissue, and the characteristics of the DCIS lesion, including ER , PR , HER2 status, grade, growth pattern, presence of calcifications or comedonecrosis, and DCIS size, as well as aberrations found in genes within the COSMIC Cancer Gene Census [ ... View More
Product Details
MA5-16348
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
proprietary
Class
Recombinant Monoclonal
Type
Antibody
Clone
SP3
Immunogen
Recombinant protein encoding extracellular domain of human c-erbB2
Conjugate
Form
Liquid
Concentration
0.122 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.2, with 1% BSA
Contains
0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is breast carcinoma.
Target Information
ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: approximately 68 kDa secreted autoinhibitor glycoprotein; c-erb B2/neu protein; CD antigen CD340; CD340; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; HER2 receptor; HER2/neu receptor; herstatin; human epidermal growth factor receptor 2; metas; Metastatic lymph node gene 19 protein; MLN 19; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; phospho ErbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; unnamed protein product; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Gene Aliases: c-ERB-2; c-ERB2; CD340; ERBB2; HER-2; HER-2/neu; HER2; MLN 19; MLN-19; MLN19; NEU; NGL; p185(erbB2); TKR1; VSCN2
UniProt ID: (Human) P04626
Entrez Gene ID: (Human) 2064
nucleotide binding
RNA polymerase I core binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane signaling receptor activity
receptor binding
protein binding
ATP binding
coreceptor activity
kinase activity
transferase activity
growth factor binding
receptor tyrosine kinase binding
identical protein binding
ErbB-3 class receptor binding
protein heterodimerization activity
protein phosphorylation
signal transduction
cell surface receptor signaling pathway
enzyme linked receptor protein signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
epidermal growth factor receptor signaling pathway
nervous system development
peripheral nervous system development
heart development
neuromuscular junction development
motor neuron axon guidance
cell proliferation
positive regulation of gene expression
Schwann cell development
peptidyl-tyrosine phosphorylation
neuron differentiation
positive regulation of cell growth
regulation of microtubule-based process
immature T cell proliferation in thymus
negative regulation of immature T cell proliferation in thymus
positive regulation of Rho protein signal transduction
intracellular signal transduction
ERBB2 signaling pathway
ERBB2-ERBB3 signaling pathway
ERBB2-EGFR signaling pathway
ERBB2-ERBB4 signaling pathway
wound healing
regulation of cell proliferation
myelination
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
protein kinase B signaling
positive regulation of translation
regulation of angiogenesis
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase I promoter
oligodendrocyte differentiation
positive regulation of epithelial cell proliferation
regulation of ERK1 and ERK2 cascade
cellular response to growth factor stimulus
cellular response to epidermal growth factor stimulus
semaphorin-plexin signaling pathway
positive regulation of protein targeting to membrane
neurotransmitter receptor localization to postsynaptic specialization membrane
positive regulation of intracellular signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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