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Invitrogen
IL-34 Monoclonal Antibody (1D12)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
MA5-17098
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1D12
Immunogen
Purified recombinant fragment of human IL34 expressed in E. Coli.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-17098 targets IL34 in indirect ELISA, FACS, ICC, IF, and WB applications and shows reactivity with Human samples.
The MA5-17098 immunogen is purified recombinant fragment of human IL34 expressed in E. Coli.
MA5-17098 detects IL34 which has a predicted molecular weight of approximately 27.5kDa.
Target Information
IL-34 is secreted as a dimeric protein and currently belongs to no known cytokine family. It signals via the M-CSF Receptor, also known as CSF-1R and CD115, which is shared with M-CSF. IL-34 has no amino acid sequence homology to M-CSF, but they exhibit similarities in secondary structure and share overlapping functions. IL-34 has been shown to promote myeloid survival, proliferation, and differentiation, and to play a role in osteoclast formation. IL-34 expression has been detected in various tissues and is most abundant in the spleen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: IL-34; ILN; Interleukin; Interleukin34; unnamed protein product
Gene Aliases: C16orf77; IL-34
UniProt ID: (Human) Q6ZMJ4
Entrez Gene ID: (Human) 146433
positive regulation of protein phosphorylation
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of cell development
positive regulation of macrophage chemotaxis
monocyte differentiation
macrophage colony-stimulating factor signaling pathway
positive regulation of MAPK cascade
positive regulation of macrophage differentiation
positive regulation of monocyte differentiation
positive regulation of oligodendrocyte differentiation
positive regulation of multicellular organismal process
interleukin-34-mediated signaling pathway
microglial cell proliferation
positive regulation of macrophage proliferation
regulation of multicellular organismal development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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