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Invitrogen

JNK1 Monoclonal Antibody (1E5)

View all (50) JNK1 antibodies

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Product Details

MA5-17117

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Flow Cytometry (Flow)

1:200-1:400
-

ELISA (ELISA)

1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1E5

Immunogen

Purified recombinant fragment of human MAPK8 expressed in E. Coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2538588

Product Specific Information

MA5-17117 targets MAPK8 in FACS, indirect ELISA, and WB applications and shows reactivity with Human and Mouse samples.

The MA5-17117 immunogen is purified recombinant fragment of human MAPK8 expressed in E. Coli.

MA5-17117 detects MAPK8 which has a predicted molecular weight of approximately 48.3kDa.

Target Information

MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is also a crucial mediator of insulin resistance and obesity. It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-Jun N-terminal kinase 1; FLJ12099; FLJ33785; JNK1 beta1 protein kinase; JUN N-terminal kinase; MAP kinase 8; MAPK 8; MAPK8; MGC50974; OTTHUMP00000019552; p493F12; p54bSAPK; protein kinase JNK1; protein kinase mitogen-activated 8; stress-activated protein kinase 1; stress-activated protein kinase 1c; stress-activated protein kinase JNK1; unnamed protein product

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Gene Aliases: JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c

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UniProt ID: (Human) P45983, (Mouse) Q91Y86

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Entrez Gene ID: (Human) 5599, (Mouse) 26419

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Function(s)
protein kinase activity protein serine/threonine kinase activity JUN kinase activity MAP kinase activity protein binding ATP binding enzyme binding protein phosphatase binding histone deacetylase regulator activity histone deacetylase binding protein serine kinase activity protein serine/threonine kinase binding protein serine/threonine/tyrosine kinase activity kinase activity kinesin binding
Process(es)
MAPK cascade protein phosphorylation response to oxidative stress JNK cascade JUN phosphorylation response to UV response to mechanical stimulus positive regulation of gene expression regulation of macroautophagy peptidyl-serine phosphorylation peptidyl-threonine phosphorylation positive regulation of cyclase activity positive regulation of cell killing negative regulation of protein binding regulation of protein localization cellular response to amino acid starvation cellular response to oxidative stress cellular response to reactive oxygen species Fc-epsilon receptor signaling pathway regulation of circadian rhythm positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of protein metabolic process stress-activated MAPK cascade cellular response to lipopolysaccharide cellular response to mechanical stimulus cellular senescence energy homeostasis positive regulation of NLRP3 inflammasome complex assembly positive regulation of establishment of protein localization to mitochondrion ossification neuron migration positive regulation of neuroblast proliferation double-strand break repair regulation of transcription, DNA-templated integrin-mediated signaling pathway neuromuscular junction development regulation of gene expression positive regulation of cardiac muscle cell apoptotic process positive regulation of cell migration positive regulation of microtubule polymerization neuron projection development positive regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of glial cell apoptotic process ERBB signaling pathway response to hydrogen peroxide regulation of mRNA stability positive regulation of neuron apoptotic process NLRP3 inflammasome complex assembly regulation of neuron differentiation positive regulation of DNA replication regulation of centrosome cycle response to cadmium ion determination of dorsal identity dendrite morphogenesis modulation of synaptic transmission SMAD protein signal transduction mRNA destabilization protein localization to tricellular tight junction protein poly-ADP-ribosylation cellular response to hydrogen peroxide cellular response to nitric oxide positive regulation of podosome assembly cellular response to oxygen-glucose deprivation type B pancreatic cell apoptotic process neuronal stem cell population maintenance programmed necrotic cell death regulation of dense core granule transport protein localization to site of double-strand break positive regulation of determination of dorsal identity positive regulation of neuron migration positive regulation of apoptotic signaling pathway
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