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Invitrogen
S100A10 Monoclonal Antibody (6F4-E6-D5-C10)
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FIGURE: 1 / 6
S100A10 Antibody (MA5-24769) in ICC/IF
Immunofluorescence analysis of Protein S100-A10 was performed using 70% confluent log phase HT-29 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with S100A10 Monoclonal Antibody (6F4-E6-D5-C10) (Product # MA5-24769) at 1:200 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa F... View More
Product Details
MA5-24769
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
6F4-E6-D5-C10
Immunogen
Purified recombinant human S100A10 protein fragments expressed in E.coli.
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Amount
150 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The S-100 family of calcium-activated proteins interact with a range of target proteins to modulate biological signaling pathways. Numerous cancer cell lines overexpress the plasminogen receptor S-100A10 on the extracellular cell surface, where it forms a heterotetrameric complex with Annexin II, though this association is not required for plasma membrane localization or binding and activation of plasminogen. Additionally, S-100A10 acts as a cellular chaperone for hepatitis B (Hep B) virus polymerase. Hep B virus polymerase normally localizes to the cytoplasm only, though in the presence of S-100A10 a portion relocates to the nucleus, implying a role for S-100A10 and intracellular calcium in the process of viral replication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Annexin II; annexin II ligand; annexin II ligand, calpactin I, light polypeptide; annexin II tetramer (AIIt) p11 subunit; calcium binding protein A11 (calgizzarin); Calpactin I light chain; Calpactin-1 light chain; Cellular ligand of annexin II; MGC111133; MGC133268; Nerve growth factor-induced protein 42C; OTTHUMP00000015270; P PRSS26; p10 protein; p11; p11 subunit; Protein S100 A10; Protein S100-A10; S-100 related protein, clone 42C; S100 calcium binding protein A10 (annexin II ligand, calpactin I, light polypeptide (p11)); S100 calcium binding protein A10 (calgizzarin); S100 calcium-binding protein A10; S100A10; unnamed protein product
Gene Aliases: 42C; AA409961; AL024248; ANX2L; ANX2LG; Ca[1]; CAL12; CAL1L; CLP11; GP11; p10; P11; S100A10
UniProt ID: (Human) P60903, (Rat) P05943, (Mouse) P08207
Entrez Gene ID: (Human) 6281, (Rat) 81778, (Mouse) 20194
membrane raft assembly
membrane budding
positive regulation of plasminogen activation
mRNA transcription from RNA polymerase II promoter
positive regulation of GTPase activity
positive regulation of exocytosis
positive regulation of transcription from RNA polymerase II promoter
regulation of neurogenesis
positive regulation of stress fiber assembly
positive regulation of focal adhesion assembly
protein localization to plasma membrane
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of plasma membrane repair
regulation of cell growth
response to antidepressant
regulation of cell differentiation
positive regulation of binding
protein heterotetramerization
establishment of protein localization to plasma membrane
cellular response to acid chemical
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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