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Invitrogen

HDAC6 Monoclonal Antibody (OTI4C5)

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HDAC6 Monoclonal Antibody (OTI4C5)

Product Details

MA5-25317

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-

Immunocytochemistry (ICC/IF)

1:100
-

Flow Cytometry (Flow)

1:100
-

ChIP assay (ChIP)

2.5 µg/10^6 cells
-
Product Specifications

Species Reactivity

Dog, Human, Non-human primate, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI4C5

Immunogen

Full length human recombinant protein of HDAC6 produced in HEK293T cell
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2723235

Target Information

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha-tubulin deacetylase HDAC6; E3 ubiquitin-protein ligase HDAC6; FLJ16239; HDA6; HDAC6; protein phosphatase 1, regulatory subunit 90; tubulin-lysine deacetylase HDAC6; unnamed protein product

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Gene Aliases: CPBHM; HD6; JM21; KDAC6; PPP1R90

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UniProt ID: (Human) Q9UBN7

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Entrez Gene ID: (Human) 10013, (Dog) 480907

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription corepressor binding histone deacetylase activity protein binding beta-catenin binding microtubule binding zinc ion binding deacetylase activity enzyme binding polyubiquitin binding ubiquitin protein ligase binding protein deacetylase activity peroxidase inhibitor activity ATPase inhibitor activity histone deacetylase binding tubulin deacetylase activity alpha-tubulin binding ubiquitin binding acetylspermidine deacetylase activity tau protein binding beta-tubulin binding misfolded protein binding Hsp90 protein binding ubiquitin protein ligase activity dynein complex binding
Process(es)
protein deacetylation misfolded or incompletely synthesized protein catabolic process intracellular protein transport response to stress epidermal growth factor receptor signaling pathway regulation of autophagy positive regulation of epithelial cell migration negative regulation of hydrogen peroxide metabolic process macroautophagy regulation of macroautophagy protein ubiquitination axonal transport of mitochondrion negative regulation of protein complex assembly regulation of protein stability protein destabilization lysosome localization positive regulation of protein oligomerization regulation of microtubule-based process positive regulation of intracellular estrogen receptor signaling pathway cellular response to heat cellular response to topologically incorrect protein negative regulation of protein complex disassembly negative regulation of gene expression, epigenetic negative regulation of proteolysis negative regulation of transcription, DNA-templated negative regulation of cellular component organization positive regulation of cellular component organization mitochondrion localization response to misfolded protein cilium morphogenesis regulation of microtubule-based movement regulation of androgen receptor signaling pathway cilium disassembly parkin-mediated mitophagy in response to mitochondrial depolarization cellular response to hydrogen peroxide aggresome assembly polyubiquitinated misfolded protein transport tubulin deacetylation macromolecule deacylation regulation of mitophagy positive regulation of type 2 mitophagy negative regulation of aggrephagy
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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