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Invitrogen
RbAp46 Monoclonal Antibody (OTI5A4)
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FIGURE: 1 / 11
RbAp46 Antibody (MA5-25715) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human breast tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a RBBP7 monoclonal antibody (Product # MA5-25715).
Product Details
MA5-25715
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5A4
Immunogen
Full length human recombinant protein of RBBP7 produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
0.84 mg/mL
Amount
84 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G1/S transition control protein-binding protein RbAp46; Histone acetyltransferase type B subunit 2; Histone-binding protein RBBP7; Nucleosome-remodeling factor subunit RBAP46; RBBP-7; RBBP7; Retinoblastoma-binding protein 7; Retinoblastoma-binding protein p46; retinoblastoma-binding protein RbAp46; unnamed protein product
Gene Aliases: RBAP46; RBBP7; SPGFX9
UniProt ID: (Human) Q16576
Entrez Gene ID: (Human) 5931
negative regulation of transcription from RNA polymerase II promoter
DNA replication
chromatin organization
chromatin remodeling
regulation of transcription, DNA-templated
brain development
negative regulation of cell growth
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of cell fate specification
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
response to steroid hormone
cellular heat acclimation
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
regulation of stem cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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