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Invitrogen
MYF5 Monoclonal Antibody (OTI2G5)
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FIGURE: 1 / 13
MYF5 Antibody (MA5-26654) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human endometrium tissue. To expose target proteins, 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min was used. Following antigen retrieval, tissues were probed with a MYF5 monoclonal antibody (Product # MA5-26654).
Product Details
MA5-26654
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2G5
Immunogen
Full length human recombinant protein of MYF5 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Myogenic factor 5 (MYF5) is a gene located on chromosome 12q21.31, encoding a basic helix-loop-helix (bHLH) transcription factor essential for skeletal muscle development and differentiation. MYF5 is one of the key members of the myogenic regulatory factor (MRF) family, which also includes MyoD, myogenin, and MRF4. It plays a crucial role in myogenesis by regulating the expression of genes necessary for muscle precursor cell proliferation and differentiation into mature muscle fibers. During embryonic development, MYF5 is involved in the formation of muscle tissue and maintenance of muscle progenitor cells. Mutations or dysregulation in MYF5 can lead to developmental abnormalities in muscle formation and are implicated in muscle-related disorders. Research into MYF5 continues to explore its regulatory mechanisms in muscle biology and potential therapeutic applications in muscular dystrophies and muscle repair processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bHLHc2; Class C basic helix-loop-helix protein 2; Myf-5; Myogenic factor 5; unnamed protein product
Gene Aliases: BHLHC2; EORVA; MYF5
UniProt ID: (Human) P13349
Entrez Gene ID: (Human) 4617
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
sequence-specific DNA binding
protein dimerization activity
E-box binding
cartilage condensation
ossification
somitogenesis
regulation of cell-matrix adhesion
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
muscle organ development
skeletal muscle tissue development
tissue development
cell differentiation
extracellular matrix organization
skeletal muscle cell differentiation
muscle cell fate commitment
camera-type eye development
positive regulation of myoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
animal organ development
muscle organ morphogenesis
embryonic skeletal system morphogenesis
positive regulation of skeletal muscle fiber development
muscle tissue morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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