Search
Invitrogen
MARK4 Monoclonal Antibody (OTI9B7)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 7
MARK4 Antibody (MA5-27002) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human lymph node tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a MARK4 monoclonal antibody (Product # MA5-27002) at a dilution of 1:150.
Product Details
MA5-27002
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI9B7
Immunogen
Human recombinant protein fragment corresponding to amino acids 390-467 of MARK4 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MARK4 is a serine/threonine kinase that is likely to be directly involved in microtubule organization in neuronal cells. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of MARK4 is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of MARK4 are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for MARK4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; FLJ90097; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase like 1; MAP/microtubule affinity-regulating kinase-like 1; MARK4 serine/threonine protein kinase; Nbla00650; unnamed protein product
Gene Aliases: KIAA1860; MARK4; MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D
UniProt ID: (Human) Q96L34
Entrez Gene ID: (Human) 57787
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
microtubule binding
cytoskeletal adaptor activity
kinase activity
transferase activity
gamma-tubulin binding
ubiquitin binding
tau protein binding
tau-protein kinase activity
protein serine kinase activity
microtubule cytoskeleton organization
microtubule bundle formation
protein phosphorylation
nervous system development
cell projection organization
intracellular signal transduction
positive regulation of programmed cell death
cilium organization
positive regulation of cilium assembly
positive regulation of cell cycle
regulation of centrosome cycle
microtubule polymerization
cell division
cilium disassembly
positive regulation of NLRP3 inflammasome complex assembly
positive regulation of protein localization to centrosome
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support