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Invitrogen
CHMP5 Monoclonal Antibody (OTI2E6)
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FIGURE: 1 / 5
CHMP5 Antibody (MA5-27018) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded carcinoma of human prostate tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a CHMP5 monoclonal antibody (Product # MA5-27018) at a dilution of 1:150.
Product Details
MA5-27018
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2E6
Immunogen
Full length human recombinant protein of CHMP5 produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein family. These proteins are components of ESCRT-III, a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies. Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptosis-related protein PNAS-2; Charged multivesicular body protein 5; Chromatin-modifying protein 5; HGNC:26942; hVps60; small protein with inherent killing effect; SNF7 domain containing 2; SNF7 domain-containing protein 2; unnamed protein product; Vacuolar protein sorting-associated protein 60; Vps60
Gene Aliases: C9orf83; CGI-34; CHMP5; HSPC177; PNAS-114; PNAS-2; SNF7DC2; Spike; Vps60
UniProt ID: (Human) Q9NZZ3
Entrez Gene ID: (Human) 51510
plasma membrane repair
regulation of receptor recycling
membrane budding
autophagy
nucleus organization
vacuolar transport
lysosome organization
mitotic metaphase plate congression
endosome to lysosome transport
regulation of centrosome duplication
protein transport
erythrocyte differentiation
nuclear envelope reassembly
late endosome to vacuole transport via multivesicular body sorting pathway
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
viral budding
viral budding from plasma membrane
vesicle fusion with vacuole
multivesicular body-lysosome fusion
midbody abscission
cellular response to lipopolysaccharide
cellular response to muramyl dipeptide
multivesicular body sorting pathway
membrane fission
autophagosome maturation
regulation of mitotic spindle assembly
late endosome to lysosome transport
ESCRT III complex disassembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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