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Invitrogen
CHIA Monoclonal Antibody (OTI3H4)
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FIGURE: 1 / 3
CHIA Antibody (MA5-27414) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human appendix tissue. To expose target proteins, heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min. Following antigen retrieval, tissues were probed with a CHIA monoclonal antibody (Product # MA5-27414) at a dilution of 1:2000.
Product Details
MA5-27414
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI3H4
Immunogen
Full length human recombinant protein of CHIA produced in E.coli
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2)-specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acidic mammalian chitinase; AMCase; chitinase precursor; Lung-specific protein TSA1902; unnamed protein product
Gene Aliases: AMCASE; CHIA; CHIT2; TSA1902
UniProt ID: (Human) Q9BZP6
Entrez Gene ID: (Human) 27159
polysaccharide catabolic process
immune system process
production of molecular mediator involved in inflammatory response
carbohydrate metabolic process
chitin metabolic process
chitin catabolic process
apoptotic process
inflammatory response
positive regulation of chemokine production
polysaccharide digestion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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