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Invitrogen
PLSCR1 Monoclonal Antibody (13A6 [TEC-23])
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![PLSCR1 Monoclonal Antibody (13A6 [TEC-23])](https://www.thermofisher.com/antibody/images/magellan/antigen/MA5-28630_PLSCR1_P58195-1_House_mouse_PDP.jpeg)
Product Details
MA5-28630
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
13A6 [TEC-23]
Immunogen
Pooled lipid rafts isolated from RBL-2H3 cells
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
15mM sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody binds to an intracellular epitope of rat Phospholipid Scramblase 1 (PLSCR1), an 37-49 kDa protein, accelerating bidirectional movement of plasma membrane phospholipids under conditions of elevated calcium.
Western Blot: Both reducing and non-reducing conditions.
Target Information
The calcium-dependent plasma membrane protein phospholipid scramblase 1 (PLSCR1) contributes to the transbilayer movement of phosphatidylserine and other membrane phospholipids upon influx of calcium into the cytosol. This movement results in plasma membrane phospholipid remodelling and surface exposure of phosphatidylserine in injured or apoptotic cells, which leads to cell death. Interferons and other cytokines induce expression of PLSCR1, implying that PLSCR1 also functions in cytokine signaling pathways. EGF stilmulation results in tyrosine phosphorylation of PLSCR1 on tyrosines 69 and 74, which allows it to interact with Shc, and thereby connecting Src kinase activation to stimulation of the EGF receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ca(2+)-dependent phospholipid scramblase 1; Mg(2+)-dependent nuclease; Phospholipid scramblase 1; phospholipid scramblase 2; PL scramblase 1
Gene Aliases: Plscr1
UniProt ID: (Rat) P58195
Entrez Gene ID: (Rat) 117540
phosphatidylserine biosynthetic process
apoptotic process
acute-phase response
immune response
positive regulation of gene expression
phospholipid transport
phospholipid scrambling
myeloid cell differentiation
negative regulation of protein binding
regulation of mast cell activation
response to interferon-alpha
response to interferon-beta
positive regulation of apoptotic process
negative regulation of viral genome replication
positive regulation of innate immune response
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
regulation of Fc receptor mediated stimulatory signaling pathway
phosphatidylserine exposure on apoptotic cell surface
cellular response to lipopolysaccharide
cellular response to cytokine stimulus
intrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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