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ITCH Monoclonal Antibody (01)

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ITCH Monoclonal Antibody (01)

Product Details

MA5-29372

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:20-1:100
-

Flow Cytometry (Flow)

1:25-1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

01

Immunogen

Recombinant Human ITCH/AIP4 protein (Arg526-Glu903)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2785246

Product Specific Information

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

This antibody has specificity for Human ITCH/AIP4.

Target Information

Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. The protein encoded by this gene interacts with atrophin-1. This encoded protein is a closely related member of the NEDD4-like protein family. This family of proteins are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. This encoded protein contains four tandem WW domains and a HECT domain. It can act as a transcriptional corepressor of p45/NFE2 and may participate in the regulation of immune responses by modifying Notch-mediated signaling. It is highly similar to the mouse Itch protein, which has been implicated in the regulation and differentiation of erythroid and lymphoid cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: AIP4; atrophin-1 interacting protein 4; Atrophin-1-interacting protein 4; dJ468O1.1; E3 ubiquitin-protein ligase Itchy homolog; HECT-type E3 ubiquitin transferase Itchy homolog; Itch; itchy E3 ubiquitin protein ligase homolog; NAPP1; Nedd 4 like ubiquitin protein ligase; NFE2-associated polypeptide 1; unnamed protein product

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Gene Aliases: ADMFD; AIF4; AIP4; ITCH; NAPP1

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UniProt ID: (Human) Q96J02

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Entrez Gene ID: (Human) 83737

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Function(s)
ubiquitin-protein transferase activity protein binding transferase activity ligase activity ubiquitin-like protein transferase activity ubiquitin-ubiquitin ligase activity ribonucleoprotein complex binding ubiquitin-like protein ligase binding CXCR chemokine receptor binding ubiquitin protein ligase activity arrestin family protein binding
Process(es)
protein polyubiquitination regulation of cell growth immune system process positive regulation of T cell anergy negative regulation of immune system process positive regulation of immune system process cytoplasmic pattern recognition receptor signaling pathway T cell anergy ubiquitin-dependent protein catabolic process protein monoubiquitination apoptotic process inflammatory response response to oxidative stress positive regulation of catabolic process regulation of gene expression positive regulation of macromolecule metabolic process protein ubiquitination protein catabolic process receptor internalization negative regulation of type I interferon production protein K29-linked ubiquitination CD4-positive, alpha-beta T cell proliferation nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway CXCL12-activated CXCR4 signaling pathway negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process innate immune response positive regulation of protein catabolic process negative regulation of JNK cascade viral entry into host cell negative regulation of defense response to virus negative regulation of multicellular organismal process defense response to virus protein autoubiquitination regulation of necroptotic process protein K63-linked ubiquitination protein K48-linked ubiquitination regulation of protein deubiquitination protein branched polyubiquitination regulation of hematopoietic stem cell differentiation negative regulation of intracellular signal transduction negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of receptor catabolic process
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